Plasma human calcitonin (hCT) levels in normal and pathologic conditions, and their responses to short calcium or tetragastrin infusion.
Plasma human calcitonin (hCT) levels in normal and pathologic conditions, and their responses to short calcium or tetragastrin infusion.
复制标题
正常和病理条件下的血浆人降钙素 (hCT) 水平及其对短期钙或四胃泌素输注的反应。
DOI：
10.1507/endocrj1954.23.517
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
N. Tanaka
中科院分区：
文献类型：
--
作者：
I. Adachi;K. Abe;Masashi Tanaka;K. Yamaguchi;S. Miyakawa;H. Hirakawa;N. Tanaka
50例正常人血浆hCT均低于50 pg/ml。在16例甲状腺髓样癌（MCT）患者中，血浆hCT水平显着升高，全甲状腺切除术后显着下降，但其中11例血浆水平仍然很高，表明存在转移。在74例其他类型的恶性肿瘤患者中，发现9例血浆hCT水平较高（3例肺燕麦细胞癌，4例恶性类癌，1例恶性嗜铬细胞瘤和1例急性髓细胞白血病）。除1例白血病外，其余肿瘤均起源于神经嵴。在12例原发性甲状旁腺功能亢进患者中，血浆hCT水平低于20 pg/ml。在13例甲状旁腺功能减退患者中，2例假性甲状旁腺功能减退，1例假性特发性甲状旁腺功能减退，血浆hCT水平略有升高。部分尿毒症患者血浆hCT水平升高，但与PTH、尿素氮、肌酐水平无相关性。作为对Ca（4.5 mg/kg/10 min）或tetragastrin（4 μ g/kg/5 min）输注的响应，在所有MCT患者中观察到血浆hCT显著增加，但在正常受试者中未观察到。在5例甲状旁腺功能减退患者中，在所有情况下也观察到两种刺激的显著增加。2例假性甲状旁腺功能减退症患者对钙负荷有反应。这些结果表明，血浆hCT水平的测定，特别是在短时间Ca或tetragastrin输注后，对于研究各种病理状况是重要的。
Plasma hCT levels were less than 50 pg/ml in 50 normal subjects. In 16 patients with medullary carcinoma of the thyroid (MCT), plasma hCT levels were distinctively elevated and they fell significantly after total thyroidectomy, but in 11 of them plasma levels were still high, indicating the presence of metastases. In 74 patients with the other types of malignancy, plasma hCT levels were found to be high in 9 cases (3 oat cell carcinoma of the lung, 4 malignant carcinoids, one malignant pheochromocytoma and one acute myelocytic leukemia). Except for the leukemic case, all these tumors were derived from neural crest. In 12 patients with primary hyperparathyroidism, plasma hCT levels were less than 20 pg/ml. In 13 hypoparathyroid patients, two with pseudohypoparathyroidism and one with pseudoidiopathic hypoparathyroidism, plasma hCT levels were slightly elevated. Some patients with uremia had elevated plasma hCT levels, but there was no relation between plasma levels of hCT and those of PTH, urea nitrogen or creatinine. In response to Ca (4.5 mg/kg/10 min) or tetragastrin (4 mug/kg/5 min) infusion, a marked increase in plasma hCT was observed in all patients with MCT, but not in normal subjects. In 5 hypoparathyroid patients, a significant increase to both stimuli was also observed in all cases. Two patients with pseudopseudohypoparathyroidism responded to the Ca load. These results indicate that the determination of plasma hCT levels especially after a short Ca or tetragastrin infusion is important to study various pathological conditions.