Comparison between the efficacy of photodynamic therapy and topical paromomycin in the treatment of Old World cutaneous leishmaniasis: a placebo-controlled, randomized clinical trial
Comparison between the efficacy of photodynamic therapy and topical paromomycin in the treatment of Old World cutaneous leishmaniasis: a placebo-controlled, randomized clinical trial
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DOI：
10.1111/j.1365-2230.2006.02182.x
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发表时间：
2006-09-01
影响因子：
4.1
通讯作者：
Davami, M.
中科院分区：
文献类型：
--
作者：
Asilian, A.;Davami, M.
皮肤利什曼病（CL）的最佳治疗方法尚不清楚。局部巴龙霉素是已建议用于治疗由利什曼原虫引起的CL的许多药物之一。最近，局部光动力疗法（PDT）已被报道是有效的治疗CL。比较PDT与局部巴龙霉素在旧世界CL患者中的寄生虫学和临床疗效。在该试验中，招募了60名临床和寄生虫学诊断为CL的患者，并将其随机分为三个治疗组，每组20名受试者。第1组每周局部PDT治疗，第2组和第3组每天两次局部巴龙霉素和安慰剂，分别。所有组的治疗持续时间均为4周。治疗结束后随访2个月，共有57例患者95处病灶完成研究。在研究结束时，第1、2和3组中分别有29/31（93.5%）、14/34（41.2%）和4/30（13.3%）处病变完全改善（P < 0.001）。在同一时间点，第1、2和3组中分别有100%、64.7%和20%的病灶获得寄生虫学治愈（P < 0.001），局部PDT可安全地用作旧世界CL的快速和高效的替代治疗选择。
The optimal treatment for cutaneous leishmaniasis (CL) is not known. Topical paromomycin is one of the many drugs that have been suggested for the treatment of CL caused by Leishmania major. Recently, topical photodynamic therapy (PDT) has been reported to be effective in the treatment of CL.To compare the parasitological and clinical efficacy of PDT vs. topical paromomycin in patients with Old World CL caused by L. major in Iran.In this trial, 60 patients with the clinical and parasitological diagnosis of CL were recruited and were randomly divided into three treatment groups of 20 subjects each. Group 1 was treated with weekly topical PDT, and groups 2 and 3 received twice-daily topical paromomycin and placebo, respectively. The duration of treatment was 4 weeks for all groups. These groups were followed for 2 months after the end of treatment.In total, 57 patients with 95 lesions completed the study. At the end of the study, complete improvement was seen in 29 of 31 (93.5%), 14 of 34 (41.2%) and 4 of 30 lesions (13.3%) in groups 1, 2 and 3, respectively (P < 0.001). At the same time point, 100%, 64.7% and 20% of the lesions had parasitological cure in group 1, 2 and 3, respectively (P < 0.001).Topical PDT can be used safely as a rapid and highly effective alternative treatment choice for Old World CL in selected patients.