Quantification of cerebral metabolites in glioma patients with proton MR spectroscopy using T2 relaxation time correction
Quantification of cerebral metabolites in glioma patients with proton MR spectroscopy using T2 relaxation time correction
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DOI：
10.1016/s0730-725x(02)00500-3
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发表时间：
2002-05-01
影响因子：
2.5
通讯作者：
Nose, T
中科院分区：
文献类型：
--
作者：
Isobe, T;Matsumura, A;Nose, T
本研究旨在利用三种不同回声时间的质子磁共振波谱(MRS)结合T2弛豫时间校正，探讨脑胶质瘤患者代谢产物绝对浓度的意义。以组织水信号为内标，用质子磁共振波谱技术测定了7例正常人和23例胶质瘤(10例低级别，13例高级别)代谢物的绝对浓度。利用T2弛豫时间对代谢产物和组织水的信号强度进行校正。与正常对照组相比，低级别脑胶质瘤患者NAA的T2松弛时间缩短，水的T2松弛时间延长(p<；0.001)。在高级别脑胶质瘤中，NAA的T2驰豫时间(p<；0.001)和肌酸的T2驰豫时间(p<；0.001)较正常组明显缩短，水的T2驰豫时间(p<；0.001)明显延长。此外，高级别胶质瘤的肌酸T2弛豫时间比低级别胶质瘤短(p<；0.05)。与正常对照组比较，脑胶质瘤组织中NAA、Cr含量降低，Cho含量升高。此外，与低级别胶质瘤相比，高级别胶质瘤的铬(P<；0.001)和CHO(P<；0.01)浓度显著降低。低铬浓度是判断胶质瘤恶性程度最可靠的指标。CHO浓度与脑胶质瘤的恶性程度无关。(C)2002 Elsevier Science Inc.保留所有权利。
This study was aimed to investigate the significance of absolute concentration of metabolites in glioma patients using proton MR spectroscopy (MRS) with T2 relaxation time correction using three different echo times. The absolute concentrations of metabolites in 7 normal subjects and in 23 gliomas (10 low-grade, 13 high-grade) were obtained by proton MRS using a tissue water signal as an internal standard. The signal intensities of metabolites and tissue water were corrected by T2 relaxation time. In low-grade glioma, the T2 relaxation time of NAA was shorter, and T2 relaxation time of water was prolonged as compared to normal subjects (p < 0.001). In high-grade glioma, the T2 relaxation time of NAA (p < 0.001) and T2 relaxation time of Cr (p < 0.01) were shorter, and T2 relaxation time of water (p < 0.001) was prolonged as compared to normal subjects. Moreover, high-grade gliomas revealed a shorter T2 relaxation time of Cr than low-grade gliomas (p < 0.05). In glioma, NAA and Cr concentration were decreased, and Cho were increased as compared to normal subjects. Moreover, high-grade glioma revealed a significant lower Cr (p < 0.001) and Cho (p < 0.01) concentration compared to low-grade gliomas. Low Cr concentration is the most reliable indicator of malignancy in glioma. Cho concentration did not correlate with malignancy in gliomas. (C) 2002 Elsevier Science Inc. All rights reserved.