Imaging glioblastoma multiforme
Imaging glioblastoma multiforme
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DOI：
10.1097/00130404-200303000-00009
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发表时间：
2003-03-01
期刊：
影响因子：
2.2
通讯作者：
Cha, S
中科院分区：
文献类型：
--
作者：
Nelson, SJ;Cha, S
多形性胶质母细胞瘤是一种浸润性病变，在不同患者内部和患者之间都具有高度的异质性。成像对于这些病变的评估和治疗的所有阶段都是至关重要的，但在提供足够可靠的信息以将患者分为行为一致的组和预测结果方面受到限制。虽然磁共振成像是可视化病变解剖特征的首选方法，但其结果在定义病变的功能特征和区分肿瘤与治疗性坏死方面是模糊的。磁共振技术的最新进展使得常规获取生理数据（如灌注和扩散加权图像）和代谢数据（如水抑制质子光谱图像）成为可能。这些提供了与肿瘤生物学特性更密切相关的定量测量，并反映了与肿瘤进展相关的肿瘤血管、细胞和增殖的变化。随着影响侵袭和肿瘤转化的分子特性的阐明，非侵入性成像技术对于研究新疗法和针对个体患者特征的定制治疗至关重要。从多形性胶质母细胞瘤患者获得的数据已经证明，这些新的磁共振技术能够有助于诊断，恶性潜能的表征，治疗计划和治疗反应的评估。
Glioblastoma multiforme are infiltrative lesions that have a high degree of heterogeneity, both within and between different patients. Imaging is critical for all phases in the evaluation and treatment of these lesions, but has been limited in providing information that is reliable enough to stratify patients into groups with uniform behavior and to predict outcome. Although magnetic resonance imaging is the method of choice for visualizing anatomic features of the lesion, its results are ambiguous in terms of defining the functional characteristics of the lesion and distinguishing tumor from treatment induced necrosis. Recent advances in magnetic resonance have made possible the routine acquisition of physiological data such as perfusion-and diffusion-weighted images and of metabolic data such as water suppressed proton spectroscopic images. These provide quantitative measurements that are more closely related to the biological properties of the tumor and reflect changes in tumor vascularity, cellularity and proliferation that are associated with tumor progression. As the molecular properties that influence invasion and neoplastic transformation are elucidated, it is critical that noninvasive imaging techniques are available for investigating new therapies and tailoring treatment to individual patient characteristics. The data obtained from patients with glioblastoma multiforme have already demonstrated that these new magnetic resonance techniques are able to contribute to diagnosis, characterization of malignant potential, treatment planning and assessment of response to therapy.