Dynorphin promotes stress‐induced depressive behaviors by inhibiting ventral pallidal neurons in rats
Dynorphin promotes stress‐induced depressive behaviors by inhibiting ventral pallidal neurons in rats
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DOI:
10.1111/apha.13882
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发表时间:
2022-08
影响因子:
6.3
通讯作者:
Miao-Jin Ji;Zhichun Gao;Jiao-jiao Yang;Ji-Heng Cai;Ke-Xue Li;Jie Wang;Hongxing Zhang;Cheng-hua Zhou;Jun-li Cao;Chao Liu
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文献类型:
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作者:
Miao-Jin Ji;Zhichun Gao;Jiao-jiao Yang;Ji-Heng Cai;Ke-Xue Li;Jie Wang;Hongxing Zhang;Cheng-hua Zhou;Jun-li Cao;Chao Liu
Endogenous dynorphin signaling via kappa opioid receptors (KORs) plays a key role in producing the depressive and aversive consequences of stress. We investigated the behavioral effects of the dynorphin/KOR system in the ventral pallidum (VP) and studied the underlying mechanisms.