Dynorphin promotes stress‐induced depressive behaviors by inhibiting ventral pallidal neurons in rats

Dynorphin promotes stress‐induced depressive behaviors by inhibiting ventral pallidal neurons in rats
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DOI:
10.1111/apha.13882
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发表时间:
2022-08
期刊:
影响因子:
6.3
通讯作者:
Miao-Jin Ji;Zhichun Gao;Jiao-jiao Yang;Ji-Heng Cai;Ke-Xue Li;Jie Wang;Hongxing Zhang;Cheng-hua Zhou;Jun-li Cao;Chao Liu
Miao-Jin Ji;Zhichun Gao;Jiao-jiao Yang;Ji-Heng Cai;Ke-Xue Li;Jie Wang;Hongxing Zhang;Cheng-hua Zhou;Jun-li Cao;Chao Liu
中科院分区:
医学1区
文献类型:
--
作者:
Miao-Jin Ji;Zhichun Gao;Jiao-jiao Yang;Ji-Heng Cai;Ke-Xue Li;Jie Wang;Hongxing Zhang;Cheng-hua Zhou;Jun-li Cao;Chao Liu

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内源性强啡肽信号通过kappa阿片受体(Kors)在应激产生抑郁和厌恶后果中起关键作用。我们研究了腹侧苍白球(VP)中强啡肽/KOR系统的行为效应,并探讨了其可能的机制。
Endogenous dynorphin signaling via kappa opioid receptors (KORs) plays a key role in producing the depressive and aversive consequences of stress. We investigated the behavioral effects of the dynorphin/KOR system in the ventral pallidum (VP) and studied the underlying mechanisms.