Physical Activity, Air Pollution, and the Risk of Asthma and Chronic Obstructive Pulmonary Disease
Physical Activity, Air Pollution, and the Risk of Asthma and Chronic Obstructive Pulmonary Disease
复制标题
DOI：
10.1164/rccm.201510-2036oc
复制
发表时间：
2016-10-01
影响因子：
24.7
通讯作者：
Andersen, Zorana J.
中科院分区：
文献类型：
--
作者：
Fisher, Jack E.;Loft, Steffen;Andersen, Zorana J.
基本原理：体力活动增强了肺部对空气污染物的吸收，可能增加了运动期间对慢性肺病的有害影响。目的：研究在城市环境中暴露于高空气污染水平是否会降低体力活动对哮喘和慢性阻塞性肺病（COPD）风险的益处。方法：来自丹麦饮食、癌症和健康队列的共53，113例受试者（50-65岁）在招募时（1993-1997年）报告了体力活动，并在国家患者登记册中随访至2013年因哮喘和COPD事件住院。在招募时估计受试者住所的二氧化氮（NO2）水平。我们使用考克斯回归将体力活动和NO2（高/中/低）与哮喘和COPD联系起来，然后在每种体力活动和NO2之间引入一个相互作用项。测量和主要结果：在16年期间，共有1，151名受试者因哮喘住院，3，225名受试者因COPD住院。我们发现参与体育运动与（风险比[95%置信区间]：0.85 [0.75-0.96]）和循环（0.85 [0.75-0.96]）患有哮喘，并且参与体育运动（0.82 [0.77-0.89]）、骑自行车（0.81 [0.76-0.87]）、园艺（0.88 [0.81-0.94]）和步行（0.85 [0.75-0.95]）。我们发现，NO2与哮喘（1.23 [1.04-1.47]）和COPD（1.15 [1.03-1.27]）住院率呈正相关（比较>= 21.0 μ g/m3和
Rationale: Physical activity enhances uptake of air pollutants in the lung, possibly augmenting their harmful effects on chronic lung disease during exercise.Objectives: To examine whether benefits of physical activity with respect to the risk of asthma and chronic obstructive pulmonary disease (COPD) are moderated by exposure to high air pollution levels in an urban setting.Methods: A total of 53,113 subjects (50-65 yr) from the Danish Diet, Cancer, and Health cohort reported physical activity at recruitment (1993-1997) and were followed until 2013 in the National Patient Register for incident hospitalizations for asthma and COPD. Levels of nitrogen dioxide (NO2) were estimated at subject residences at the time of recruitment. We used Cox regression to associate physical activities and NO2 (high/medium/low) with asthma and COPD, and then introduced an interaction term between each physical activity and NO2.Measurements and Main Results: A total of 1,151 subjects were hospitalized for asthma and 3,225 for COPD during 16 years. We found inverse associations of participation in sports (hazard ratio [95% confidence interval]: 0.85 [0.75-0.96]) and cycling (0.85 [0.75-0.96]) with incident asthma, and of participation in sports (0.82 [0.77-0.89]), cycling (0.81 [0.76-0.87]), gardening (0.88 [0.81-0.94]), and walking (0.85 [0.75-0.95]) with incident COPD admissions. We found positive associations between NO2 and incident asthma (1.23 [1.04-1.47]) and COPD (1.15 [1.03-1.27]) hospitalizations (comparing >= 21.0 mu g/m(3) to