Tracking brain arousal fluctuations with fMRI
Tracking brain arousal fluctuations with fMRI
复制标题
DOI：
10.1073/pnas.1520613113
复制
发表时间：
2016-04-19
影响因子：
11.1
通讯作者：
Duyn, Jeff H.
中科院分区：
文献类型：
--
作者：
Chang, Catie;Leopold, David A.;Duyn, Jeff H.
大脑活动的变化伴随着警觉和觉醒的变化，可能会干扰对大脑功能的其他内在和任务诱发特征的研究。然而，在功能磁共振成像（fMRI）的唤醒状态的跟踪和建模的困难，通常排除了唤醒依赖的影响，对fMRI信号的评估。在这里，我们结合联合收割机功能磁共振成像，电生理学，和眼睑行为的监测，以证明一种方法，跟踪连续变化的唤醒水平从功能磁共振成像数据。我们首先表征的空间分布的功能磁共振成像信号波动，跟踪的行为觉醒的措施，以这种模式为模板，并使用局部场电位作为一个同时和独立的测量皮质活动，我们观察到，随时间变化的表达水平的功能磁共振成像数据中的模板提供了一个密切的近似电生理觉醒。我们讨论了这些研究结果的潜在好处，增加作为认知和临床生物标志物的功能磁共振成像的灵敏度。
Changes in brain activity accompanying shifts in vigilance and arousal can interfere with the study of other intrinsic and task-evoked characteristics of brain function. However, the difficulty of tracking and modeling the arousal state during functional MRI (fMRI) typically precludes the assessment of arousal-dependent influences on fMRI signals. Here we combine fMRI, electrophysiology, and the monitoring of eyelid behavior to demonstrate an approach for tracking continuous variations in arousal level from fMRI data. We first characterize the spatial distribution of fMRI signal fluctuations that track a measure of behavioral arousal; taking this pattern as a template, and using the local field potential as a simultaneous and independent measure of cortical activity, we observe that the time-varying expression level of this template in fMRI data provides a close approximation of electrophysiological arousal. We discuss the potential benefit of these findings for increasing the sensitivity of fMRI as a cognitive and clinical biomarker.