Clinical impact of 18F-FDG PET/CT on the management and diagnosis of infectious spondylitis
Clinical impact of 18F-FDG PET/CT on the management and diagnosis of infectious spondylitis
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DOI：
10.1097/mnm.0b013e32833bb25d
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发表时间：
2010-08-01
影响因子：
1.5
通讯作者：
Mimori, Akio
中科院分区：
文献类型：
--
作者：
Ito, Kimiteru;Kubota, Kazuo;Mimori, Akio
目的评价（18）f -氟脱氧葡萄糖（FDG）正电子发射断层扫描(PET)/计算机断层扫描（CT）对感染性脊柱炎患者治疗的影响。材料与方法回顾性分析29例感染性脊柱炎（结核性脊柱炎9例，化脓性脊柱炎20例）行F-FDG PET/ ct检查的临床资料；共检出病灶42个。对感染治疗临床管理的有用影响（开始或更长时间的抗生素治疗，或手术干预等）被定义为强影响，而从（18）F-FDG PET/CT获得不影响感染治疗临床管理的新信息被定义为弱影响。无影响定义为没有获得任何影响感染治疗的新信息。结果（18）F-FDG PET/CT对52%（29例中15例）患者的临床管理有较强影响。（18）F-FDG PET/CT检出临床未发现的脊柱炎10例，人工移植物感染1例，延长治疗期。在5例结核性脊柱炎患者中，使用（18）F-FDG PET/CT图像确定3例患者的活检部位，2例患者确定哪些病变需要手术。结论（18）F-FDG PET/CT对感染性脊柱炎的诊断有一定的价值。核医学通讯：691-698 (C) 2010 Wolters Kluwer健康垂直酒吧Lippincott Williams & Wilkins。
Objective The aim of this study was to evaluate the impact of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) on the management of patients with infectious spondylitis.Materials and methods Twenty-nine patients with infectious spondylitis (9 with tuberculous spondylitis and 20 with pyogenic spondylitis) who had undergone an (18)F-FDG PET/CTexamination were retrospectively evaluated; 42 lesions were detected. A useful impact on the clinical management of infection therapy (start or longer duration of antibiotic therapy, or surgical intervention, etc) was defined as a strong impact, whereas gaining new information not affecting the clinical management of infection therapy from (18)F-FDG PET/CT was defined as a weak impact. No impact was defined as not obtaining any new information influencing infection therapy.Results (18)F-FDG PET/CT had a strong impact on the clinical management of 52% (15 of 29) of the patients. (18)F-FDG PET/CT detected 10 cases of spondylitis and one artificial graft infection that the clinician had not recognized, and the therapeutic period was extended in these patients. In five patients with tuberculous spondylitis, the (18)F-FDG PET/CT images were used to decide the biopsy sites in three patients and to determine which lesions required surgery in two patients.Conclusion (18)F-FDG PET/CT is useful for detecting infectious spondylitis. Nucl Med Commun 31:691-698 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.