Localization and upregulation of survivin in cancer health disparities: a clinical perspective.
Localization and upregulation of survivin in cancer health disparities: a clinical perspective.
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DOI：
10.2147/btt.s83864
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wall NR
中科院分区：
文献类型：
--
作者：
Khan S;Ferguson Bennit H;Asuncion Valenzuela MM;Turay D;Diaz Osterman CJ;Moyron RB;Esebanmen GE;Ashok A;Wall NR
Survivin是凋亡抑制蛋白家族中最重要的成员之一，因为它在大多数人类肿瘤中都有表达，但在正常分化的组织中不表达。更重要的是，Survivin已被证明与细胞凋亡和细胞周期控制有关，最近被证明由于其细胞外定位而调节肿瘤微环境和免疫逃避。Survivin的表达上调在包括乳腺癌、前列腺癌、胰腺癌和血液系统恶性肿瘤在内的许多癌症中都被发现，它可能被证明与在不同种族人群中观察到的晚期临床表现、较差的预后和较低的存活率有关。
Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with apoptosis and cell cycle control, and has more recently been shown to modulate the tumor microenvironment and immune evasion as a result of its extracellular localization. Upregulation of survivin has been found in many cancers including breast, prostate, pancreatic, and hematological malignancies, and it may prove to be associated with the advanced presentation, poorer prognosis, and lower survival rates observed in ethnically diverse populations.