Base sequence selectivity in binding of aromatic hydrocarbons with synthetic polynucleotides.
Base sequence selectivity in binding of aromatic hydrocarbons with synthetic polynucleotides.
复制标题
芳香烃与合成多核苷酸结合的碱基序列选择性。
DOI：
10.1016/0006-291x(83)91586-3
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发表时间：
1983
影响因子：
3.1
通讯作者：
Yang,DD
中科院分区：
文献类型：
--
作者：
Yang,NC;Hrinyo,TP;Petrich,JW;Yang,DD
本文用光谱技术研究了DOBP（3）与小牛胸腺DNA及四种人工合成的多聚核苷酸（poly（dA-dT），polydA：polydT，poly（dG-dC），polydG：polydC）的相互作用。发现3与poly（dA-dT）的结合明显优于其他合成的多核苷酸和DNA。结果表明，致癌的BPDE（2）与DNA的初始结合可能优先发生在DNA中某些特定的碱基序列上。
The interactions between DOBP (3) and calf thymus DNA as well as four synthetic polynucleotides, poly (dA-dT), polydA: polydT, poly (dG-dC), and polydG: polydC, were investigated by spectroscopic techniques. It was found that the binding of 3 with poly (dA-dT) is favored appreciably over other synthetic polynucleotides and DNA. The results suggest that the initial association of carcinogenic BPDE (2) with DNA may take place preferentially at certain specific base sequences in DNA.