Biphasic radiosensitization of human lymphocytes by diethyldithiocarbamate: possible involvement of superoxide dismutase.
Biphasic radiosensitization of human lymphocytes by diethyldithiocarbamate: possible involvement of superoxide dismutase.
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二乙基二硫代氨基甲酸酯对人淋巴细胞的双相放射增敏：可能涉及超氧化物歧化酶。
DOI：
10.1080/09553008014551621
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Head,C
中科院分区：
文献类型：
--
作者：
Rigas,DA;Eginitis-Rigas,C;Bigley,RH;Stankova,L;Head,C
本文观察了金属螯合剂二乙基二硫代氨基甲酸盐（DDC）对人淋巴细胞的双相放射增敏作用。第一个相位发生在10−5M DDC，第二个相位发生在10−3M DDC。双相放射增敏与以前报道的DDC的双相毒性一致。超氧化物歧化酶（SOD）的抑制只发生在第二阶段，这表明它可能是这个阶段的一个促成因素。第一个放射增敏阶段的机制尚不清楚。辐射存活曲线表明，至少存在两种淋巴细胞群，它们的辐射敏感性不同，分别占细胞的40%和60%。两种细胞群均被DDC双相放射增敏。
A biphasic radiosensitization of human lymphocytes by diethyldithiocarbamate (DDC), a metal chelator, was observed. The first phase occurred at 10−5M and the second at 10−3M DDC. The biphasic radiosensitization coincided with the previously reported biphasic toxicity of DDC. Inhibition of superoxide dismutase (SOD) occurred only in the second phase, suggesting that it may be a contributing cause of this phase. The mechanism of the first radiosensitization phase is not known. The radiation survival curves indicated the presence of at least two lymphocyte populations differing in their radiosensitivity and representing 40 per cent and 60 per cent of the cells. Both cell populations were biphasically radiosensitized by DDC.