Interacting signaling pathways controlling multicellular development in Dictyostelium
Interacting signaling pathways controlling multicellular development in Dictyostelium
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DOI：
10.1016/s0959-437x(96)80082-7
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发表时间：
1996-10-01
影响因子：
4
通讯作者：
Firtel, RA
中科院分区：
文献类型：
--
作者：
Firtel, RA
CAMP是关键的细胞外信号分子，通过经典的G蛋白偶联/蛇纹石受体控制网柄网柄菌的发育。聚集是由cAMP的纳摩尔脉冲控制的，而更连续的微摩尔信号通过受体介导的非G蛋白偶联途径激活转录级联来控制多细胞分化。讨论了细胞外cAMP功能差异化控制聚集、形态发生和细胞类型分化的可能机制。该综述还总结了一些新的发现，阐明了该生物体中控制细胞类型调控的途径，包括由糖原合成酶激酶3和cAMP依赖的蛋白激酶介导的信号级联反应，后生动物细胞类型分化的关键调节因子，以及新发现的转录因子。
cAMP functions as the key extracellular signaling molecule controlling Dictyostelium development acting through classic G-protein-coupled/serpentine receptors. Whereas aggregation is controlled by nanomolar pulses of cAMP, a more continuous micromolar signal controls multicellular differentiation by activating a transcriptional cascade via a receptor-mediated but non G-protein-coupled pathway. Potential mechanisms by which extracellular cAMP functions to differentially control aggregation followed by morphogenesis and cell-type differentiation are discussed. This review also summarizes new findings elucidating pathways controlling cell-type regulation in this organism, including signaling cascades mediated by glycogen synthase kinase 3 and cAMP-dependent protein kinase, key regulators of cell-type differentiation in metazoans, and newly identified transcription factors.