Dehalogenation of lindane by a variety of porphyrins and corrins
Dehalogenation of lindane by a variety of porphyrins and corrins
复制标题
多种卟啉和咕啉对林丹的脱卤反应
DOI：
10.1128/aem.55.5.1258-1261.1989
复制
发表时间：
1989
影响因子：
4.4
通讯作者：
A. Maule
中科院分区：
文献类型：
--
作者：
T. S. Marks;J. D. Allpress;A. Maule
在二硫苏糖醇存在的还原条件下，已经测试了一系列的血色素蛋白、卟啉和Corins对林丹的脱卤化作用。此外，还制备了一系列的卟啉-金属离子络合物，并对其脱卤化林丹的能力进行了筛选。血红蛋白、氯化血红素、血红素和叶绿素α都催化了林丹的脱卤化反应，所有被测试的科林素都是如此。不含金属中心的卟啉--共比例卟啉、血卟啉、原卟啉和尿卟啉--是不活跃的。然而，当这些卟啉与钴、铁、镁、钼、镍或钒配位时，观察到了林丹脱卤化反应。在所有情况下，反应都是通过初始脱氯生成四氯环己烯，再进一步脱卤化生成氯苯作为最终产物。
The dehalogenation of lindane by a range of hemoproteins, porphyrins, and corrins has been tested under reducing conditions in the presence of dithiothreitol. In addition, a series of porphyrin-metal ion complexes have been prepared and have also been screened for the capacity to dehalogenate lindane. Hemoglobin, hemin, hematin, and chlorophyll alpha all catalyzed the dehalogenation of lindane, as did all of the corrins tested. The porphyrins which did not contain metal centers--coproporphyrin, hematoporphyrin, protoporphyrin, and uroporphyrin--were inactive. However, when these porphyrins were then complexed with Co, Fe, Mg, Mo, Ni, or V, lindane dehalogenation was observed. In all cases, the reaction proceeded by an initial dechlorination to produce tetrachlorocyclohexene, which was further dehalogenated to yield chlorobenzene as the end product.