Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for Bacillus subtilis
Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for Bacillus subtilis
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DOI：
10.1099/mic.0.035790-0
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发表时间：
2010-03-01
期刊：
影响因子：
2.8
通讯作者：
Stuelke, Joerg
中科院分区：
文献类型：
--
作者：
Lammers, Christoph R.;Florez, Lope A.;Stuelke, Joerg
枯草芽孢杆菌是一大群革兰氏阳性菌厚壁菌门的模式生物。随着时间的推移，已经建立了几个在线数据库来管理其遗传和代谢信息，但它们在更新速度和对B的关注方面存在很大差异。枯草芽孢杆菌因此，一个欧洲系统生物学联盟呼吁提供一种综合解决方案，使其用户能够丰富在线内容。为了实现这一目标，我们创建了SubtiWiki和SubtiPathways，这是两个关于B基因和途径信息的互补在线工具。subtilis 168. SubtiWiki（http：//subtiwiki.uni-goettingen.de/）是一个关于B所有基因的科学维基。枯草芽孢杆菌及其蛋白质或RNA产物。每个基因网页包含最重要信息的摘要;关于基因、其产物和表达的部分;关于生物材料和实验室的部分;以及参考文献列表。SubtiWiki已经植入了关键内容，任何研究人员都可以在简单的注册后进行扩展，从而使其始终保持最新状态。作为补充，SubtiPathways（http：//subtipathways.uni-goettingen.de/）是一种用于导航B代谢的在线工具。枯草芽孢杆菌及其调控每个SubtiPathways图都以基于Google地图的直观界面呈现了代谢途径及其参与酶，以及作用于其表达和活性的调节机制。SubtiWiki和SubtiPathways一起提供了组成B的过程的集成视图。枯草芽孢杆菌及其组分，使其成为B最全面的网络资源。subtilis的研究人员。
Bacillus subtilis is the model organism for a large group of Gram-positive bacteria, the Firmicutes. Several online databases have been established over time to manage its genetic and metabolic information, but they differ greatly in their rate of update and their focus on B. subtilis. Therefore, a European systems biology consortium called for an integrated solution that empowers its users to enrich online content. To meet this goal we created SubtiWiki and SubtiPathways, two complementary online tools for gene and pathway information on B. subtilis 168. SubtiWiki (http://subtiwiki.uni-goettingen.de/) is a scientific wiki for all genes of B. subtilis and their protein or RNA products. Each gene page contains a summary of the most important information; sections on the gene, its product and expression; sections concerning biological materials and laboratories; and a list of references. SubtiWiki has been seeded with key content and can be extended by any researcher after a simple registration, thus keeping it always up to date. As a complement, SubtiPathways (http://subtipathways.uni-goettingen.de/) is an online tool for navigation of the metabolism of B. subtilis and its regulation. Each SubtiPathways diagram presents a metabolic pathway with its participating enzymes, together with the regulatory mechanisms that act on their expression and activity, in an intuitive interface that is based on Google Maps. Together, SubtiWiki and SubtiPathways provide an integrated view of the processes that make up B. subtilis and its components, making it the most comprehensive web resource for B. subtilis researchers.