ANTIBODY-GUIDED RADIOLOCALIZATION OF TUMORS IN PATIENTS WITH TESTICULAR OR OVARIAN-CANCER USING 2 RADIOIODINATED MONOCLONAL-ANTIBODIES TO PLACENTAL ALKALINE-PHOSPHATASE
ANTIBODY-GUIDED RADIOLOCALIZATION OF TUMORS IN PATIENTS WITH TESTICULAR OR OVARIAN-CANCER USING 2 RADIOIODINATED MONOCLONAL-ANTIBODIES TO PLACENTAL ALKALINE-PHOSPHATASE
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DOI：
10.1259/0007-1285-59-698-117
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发表时间：
1986-02-01
影响因子：
2.6
通讯作者：
LAVENDER, JP
中科院分区：
文献类型：
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作者：
EPENETOS, AA;CARR, D;LAVENDER, JP
抗胎盘型碱性磷酸酶和睾丸胎盘样碱性磷酸酶的单克隆抗体（H317和H17 E2）用123 I或131 I放射性标记，并用于睾丸生殖细胞肿瘤（13项研究）或卵巢上皮源性肿瘤（13项研究）患者的前瞻性研究。通过抗体扫描，在大多数活动性疾病患者中证实了肿瘤的存在。在完全缓解的患者中，所有病例均证实无肿瘤。在两名抗体扫描阳性但常规放射学评估未发现疾病的患者中，随后的进一步调查显示存在肿瘤。阳性抗体扫描表明明确存在肿瘤，尽管阴性抗体扫描并不总是排除疾病的存在。这种方法可能是临床价值，在建立疾病状态的患者具有潜在的可治愈的疾病，如卵巢癌或睾丸癌。
Monoclonal antibodies (H317 and H17E2) against placental-type alkaline phosphatase and testicular placental-like alkaline phosphatase were radiolabelled with 123I or 131I and used in a prospective study of patients with germ-cell neoplasms of the testis (13 studies) or epithelial-origin neoplasms of the ovary (13 studies). The presence of tumour was confirmed in the majority of patients with active disease by antibody scanning. The absence of tumor was confirmed in all cases in patients in complete remission. In two patients with positive antibody scans but no disease found by conventional radiological evaluation, further investigation subsequently revealed the presence of tumor. A positive antibody scan indicates the definite presence of a tumour, although a negative antibody scan does not always exclude the presence of disease. This method may be of clinical value in establishing disease status in patients with potentially curable diseases such ovarian or testicular cancers.