! Longitudinal Performance of Plasma Neurofilament Light and Tau in Professional Fighters: The Professional Fighters Brain Health Study
! Longitudinal Performance of Plasma Neurofilament Light and Tau in Professional Fighters: The Professional Fighters Brain Health Study
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DOI：
10.1089/neu.2017.5553
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发表时间：
2018-07-11
影响因子：
4.2
通讯作者：
Blennow, Kaj
中科院分区：
文献类型：
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作者：
Bernick, Charles;Zetterberg, Henrik;Blennow, Kaj
本研究的目的是评估职业拳击手血浆神经丝光 (NF-L) 和 tau 蛋白水平的纵向变化与临床和放射学测量的关系。参与者（现役和退役职业战士以及对照组）每年接受血液采样、3-特斯拉磁共振成像 (MRI) 脑成像、计算机认知测试以及创伤性脑损伤暴露评估。使用 Simoa 测定法测量血浆 tau 和 NF-L 浓度。多元线性回归模型用于比较基线测量方面的组间差异，而混合线性模型用于每个参与者的多个测量的纵向数据。提供了 471 名参与者的血浆样本。各组的基线 NF-L 测量值不同（F-3、F-393=6.99；p=0.0001），活跃拳击手的水平最高。基线时较高的 NF-L 水平与较低的基线 MRI 区域体积和较低的认知评分相关。现役拳手完成的陪练回合数与 NF-L 水平相关（95% 置信区间，0.0116-0.4053；p=0.0381），但与 tau 水平无关。在具有多个年度样本的 126 名受试者中，各组之间 tau 的平均年度百分比变化存在显着差异（F-3、F-83=3.87；p=0.0121）。我们得出结论，血浆 NF-L 和 tau 在一组现役和退役战士中表现不同； NF-L 更好地反映了急性暴露，而血浆 tau 水平在表明大脑结构随时间的慢性变化中的作用需要进一步研究。
The aim of this study is to evaluate longitudinal change in plasma neurofilament light (NF-L) and tau levels in relationship to clinical and radiological measures in professional fighters. Participants (active and retired professional fighters and control group) underwent annual blood sampling, 3-Tesla magnetic resonance imaging (MRI) brain imaging, computerized cognitive testing, and assessment of exposure to traumatic brain injury. Plasma tau and NF-L concentrations were measured using Simoa assays. Multiple linear regression models were used to compare the difference across groups in regard to baseline measurements, whereas mixed linear models was used for the longitudinal data with multiple measurements for each participant. Plasma samples were available on 471 participants. Baseline NF-L measures differed across groups (F-3,F-393=6.99; p=0.0001), with the active boxers having the highest levels. Higher NF-L levels at baseline were correlated with lower baseline MRI regional volumes and lower cognitive scores. The number of sparring rounds completed by the active fighters was correlated with NF-L (95% confidence interval, 0.0116-0.4053; p=0.0381), but not tau, levels. Among 126 subjects having multiple yearly samples, there was a significant difference in average yearly percentage change in tau across groups (F-3,F-83=3.87; p=0.0121). We conclude that plasma NF-L and tau behave differently in a group of active and retired fighters; NF-L better reflects acute exposure whereas the role of plasma tau levels in signifying chronic change in brain structure over time requires further study.