Regulating the pro- and anti-oxidant capabilities of bimetallic nanozymes for the detection of Fe2+ and protection of Monascus pigments
Regulating the pro- and anti-oxidant capabilities of bimetallic nanozymes for the detection of Fe2+ and protection of Monascus pigments
复制标题
调节双金属纳米酶的促氧化和抗氧化能力，用于检测 Fe2 和保护红曲色素
DOI：
10.1039/c9nr10135g
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发表时间：
2020-02-07
期刊：
影响因子：
6.7
通讯作者：
Yin, Jun-jin
中科院分区：
文献类型：
--
作者：
Liu, Chuang;Yan, Yingying;Yin, Jun-jin
模拟酶的新特性为纳米材料开辟了新的视野。调控其类酶活性并开发其应用是目前纳米酶研究的热点。在它们的活动中，纳米酶的促氧化和抗氧化能力对于确定其独特的生理功能是重要的。在本文中，我们证明了PtRu纳米颗粒具有多种酶样活性（如过氧化物酶，氧化酶，铁氧化酶，过氧化氢酶和SOD）和1，1-二苯基-2-苦肼基（DPPH）自由基清除活性。因此，PtRu纳米酶显示出促氧化和抗氧化功能。发现PtRu纳米颗粒的类酶活性高度依赖于Pt/Ru摩尔比，并且在活性顺序上显示出类似的趋势：Pt 90 Ru 10> Pt 75 Ru 25> Pt > Pt 40 Ru 60，表明Pt与Ru的适当合金化可以增强促氧化和抗氧化能力。利用类铁氧化酶和类过氧化氢酶的活性，验证了PtRu纳米酶在Fe 2+检测中的应用，并首次尝试保护Monoclonal色素（MPs）免受H2 O2氧化。这些结果不仅为优化纳米酶的促氧化和抗氧化能力提供了有效途径，而且为纳米酶在保护生物活性天然产物中的应用提供了前景。
The emerging properties of mimicking enzymes open up new horizons for nanomaterials. Regulating their enzyme-like activity and exploiting their applications are currently the hot topics for nanozymes. Among their activities, the pro-oxidant and antioxidant capabilities of nanozymes are important to determine their unique physiological functions. In this paper, we demonstrate that PtRu NPs exhibit multiple enzyme-like activities (e.g. peroxidase, oxidase, ferroxidase, catalase and SOD) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. The PtRu bimetallic nanozymes therefore show pro-oxidant and anti-oxidant functions. It was found that the enzyme-like activities of PtRu NPs are highly dependent on the Pt/Ru molar ratio and show a similar trend in the order of activity: Pt90Ru10 > Pt75Ru25 > Pt > Pt40Ru60, indicating that proper alloying of Pt with Ru can enhance both pro- and anti-oxidant capabilities. By employing the ferroxidase-like activity and catalase-like activity, we verified the applications of PtRu nanozymes in the detection of Fe2+ ions, and tried for the first time to protect Monascus pigments (MPs) from hydrogen peroxide oxidation. These results not only provide an effective way to optimize the pro- and anti-oxidant capabilities of nanozymes, but also provide prospects for the applications of nanozymes in protecting biologically active natural products.