Effects of Habitual Alcohol Intake on Ambulatory Blood Pressure, Heart Rate, and Its Variability Among Japanese Men
Effects of Habitual Alcohol Intake on Ambulatory Blood Pressure, Heart Rate, and Its Variability Among Japanese Men
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DOI：
10.1161/hypertensionaha.108.114835
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发表时间：
2009-01-01
期刊：
影响因子：
8.3
通讯作者：
Iso, Hiroyasu
中科院分区：
文献类型：
--
作者：
Ohira, Tetsuya;Tanigawa, Takeshi;Iso, Hiroyasu
我们试图研究日本男性中习惯性饮酒对动态血压（BP）、心率（HR）和HR变异性的影响。研究对象为来自农村和城市社区的539名35至65岁的男性。动态血压和心率监测与自动化，便携式，非侵入性多生物医学记录仪。每5分钟对ECG上的RR间期进行一次功率谱分析。与不饮酒者相比，中度饮酒者（酒精摄入量23 - 45 g/d）和重度饮酒者（酒精摄入量≥ 46 g/d）在早晨和清醒时显示出较高的年龄和现场校正的收缩压和舒张压平均值，但在24小时内和睡眠时，酒精摄入量类别之间的血压没有差异。酒精摄入量与BP的睡眠-早晨差异平均值和日间变异性、清醒和睡眠时的心率以及睡眠时的低频：高频比正相关。在调整了体重指数、吸烟和糖尿病后，结果几乎没有变化。与不饮酒者相比，早晨血压升高的年龄和场地调整优势比（早晨血压过度升高：早晨收缩压减去睡眠收缩压>= 37 mm Hg）（酒精摄入量0至22 g/d），中度和重度饮酒者为0.96（95%CI：0.34至2.78）、1.68（95%CI：0.64至4.38）和2.73（95%CI：1.12至6.67）。习惯性酒精摄入与早晨血压升高、清醒和睡眠时心率升高以及睡眠时交感神经活动相关，这可能解释了大量酒精摄入与心血管疾病风险之间关系的一些机制。（高血压。2009; 53：13-19.）
We sought to examine effects of habitual alcohol intake on ambulatory blood pressure (BP), heart rate (HR), and HR variability among Japanese men. Subjects were 539 men aged 35 to 65 years from rural and urban communities. Ambulatory BP and HR were monitored with an automated, portable, noninvasive multibiomedical recorder. Power spectral analysis of the RR intervals on the ECG was performed every 5 minutes. Compared with nondrinkers, moderate drinkers (alcohol intake 23 to 45 g/d) and heavy drinkers (alcohol intake >= 46 g/d) showed higher age- and field-adjusted mean values of systolic and diastolic BPs during the morning and while awake, but there were no differences in BPs over 24-hour periods and while asleep among the alcohol intake categories. Alcohol intake was positively associated with mean values of sleep-morning differences and daytime variability in BPs, HRs while awake and asleep, and low frequency: high frequency ratio while asleep. The results were virtually unchanged after adjustment for body mass index, smoking, and diabetes mellitus. Compared with the nondrinkers, age- and field-adjusted odds ratios of the morning BP surge (excess elevation of BP in the morning: morning systolic BP minus sleep systolic BP >= 37 mm Hg) for light (alcohol intake 0 to 22 g/d), moderate, and heavy drinkers were 0.96 (95% CI: 0.34 to 2.78), 1.68 (95% CI: 0.64 to 4.38), and 2.73 (95% CI: 1.12 to 6.67), respectively. Habitual alcohol intake was associated with increased BP in the morning, HR while awake and asleep, and sympathetic activity while asleep, which may explain some of the mechanisms of the relationship between heavy alcohol intake and risk of cardiovascular diseases. (Hypertension. 2009; 53: 13-19.)