Episodic simulation of future events is impaired in mild Alzheimer's disease
Episodic simulation of future events is impaired in mild Alzheimer's disease
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DOI：
10.1016/j.neuropsychologia.2009.05.018
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发表时间：
2009-10-01
期刊：
影响因子：
2.6
通讯作者：
Schacter, Daniel L.
中科院分区：
文献类型：
--
作者：
Addis, Donna Rose;Sacchetti, Daniel C.;Schacter, Daniel L.
最近的神经影像学研究表明，记住过去和模拟未来都会激活包括内侧颞叶在内的核心神经网络。该网络的区域，特别是内侧颞叶，是淀粉样蛋白沉积的主要部位，并且在阿尔茨海默病（AD）中在结构和功能上受到损害。虽然我们知道这个核心网络的一些功能，特别是情景自传记忆，在 AD 中受到损害，但没有研究检查未来的情景模拟是否也会受到类似的损害。我们使用自传访谈的改编版本测试了 16 名 AD 患者和 16 名年龄匹配的对照者生成过去和未来自传事件的能力。参与者还产生了一生中五个遥远的自传体记忆。事件转录被分割成不同的细节，分为内部（情景）或外部（非情景）。 AD 患者在记忆过去事件和模拟未来事件方面都表现出缺陷，与健康的老年对照组相比，产生的内部和外部情景细节更少。内部和外部细节得分与过去和未来的事件密切相关，进一步证明了过去和未来的心理表征之间的密切联系。 (C) 2009 Elsevier Ltd. 保留所有权利。
Recent neuroimaging studies have demonstrated that both remembering the past and simulating the future activate a core neural network including the medial temporal lobes. Regions of this network, in particular the medial temporal lobes, are prime sites for amyloid deposition and are structurally and functionally compromised in Alzheimer's disease (AD). While we know some functions of this core network, specifically episodic autobiographical memory, are impaired in AD, no study has examined whether future episodic simulation is similarly impaired. We tested the ability of sixteen AD patients and sixteen age-matched controls to generate past and future autobiographical events using an adapted version of the Autobiographical Interview. Participants also generated five remote autobiographical memories from across the lifespan. Event transcriptions were segmented into distinct details, classified as either internal (episodic) or external (non-episodic). AD patients exhibited deficits in both remembering past events and simulating future events, generating fewer internal and external episodic details than healthy older controls. The internal and external detail scores were strongly correlated across past and future events, providing further evidence of the close linkages between the mental representations of past and future. (C) 2009 Elsevier Ltd. All rights reserved.