Ethnicity and skin test reactivity to aeroallergens among asthmatic children in Connecticut
Ethnicity and skin test reactivity to aeroallergens among asthmatic children in Connecticut
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DOI：
10.1378/chest.125.1.85
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发表时间：
2004-01-01
期刊：
影响因子：
9.6
通讯作者：
Cloutier, M
中科院分区：
文献类型：
--
作者：
Celedón, JC;Sredl, D;Cloutier, M
目的：在康涅狄格州城市和郊区的哮喘儿童中，研究种族与过敏原敏感性之间的关系。研究设计：横断面研究。研究人群：共有791名在哈特福德市接受医疗护理的轻度至重度哮喘儿童。结果：波多黎各种族与蟑螂皮肤试验反应性（STR）相关（比值比[OR]，3.3; 95%置信区间[CI]，1.7至6.4），STR与尘螨（OR，1.7; 95% CI，1.2至2.4），STR与混合草花粉（OR，1.7; 95% CI，1.1至2.7），STR与艾蒿/鼠尾草（OR，2.4; 95% CI，1.4至4.1）。非裔美国人种族与四种户外过敏原的STR相关（即，混合树花粉[OR，2.3; 95% CI，1.3 - 3.9]，混合草花粉[OR，2.7; 95% CI，1.6 - 4.8]，艾蒿/鼠尾草[OR，3.1; 95% CI，1.6 - 6.0]和豚草[OR，2.1; 95%CI，1.2至3.8]）。在所有儿童中，对户外过敏原的STR与过敏原致敏程度密切相关。例如，对混合草花粉过敏的儿童至少有四次对其他过敏原的阳性皮肤试验的几率比非过敏儿童高34.7倍（OR的95% CI，15.6至77.0）。我们的研究结果表明，波多黎各种族与哮喘儿童对室内和室外过敏原致敏的风险增加有关，过敏皮肤试验应更经常地作为非裔美国儿童和美国波多黎各儿童哮喘管理的一部分。
Objectives: To examine the relationship between ethnicity and sensitization to allergens among children with asthma living in urban and suburban areas of Connecticut.Study design: Cross-sectional study.Study population: A total of 791 children with mild-to-severe asthma who received their medical care in the city of Hartford.Results: Puerto Rican ethnicity was associated with skin test reactivity (STR) to cockroach (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.7 to 6.4), STR to dust mite (OR, 1.7; 95% CI, 1.2 to 2.4), STR to mixed grass pollen (OR, 1.7; 95% CI, 1.1 to 2.7), and STR to mugwort/sage (OR, 2.4; 95% CI, 1.4 to 4.1). African-American ethnicity was associated with STR to four outdoor allergens (ie, mixed tree pollen [OR, 2.3; 95% CI, 1.3 to 3.9], mixed grass pollen [OR, 2.7; 95% CI, 1.6 to 4.8], mugwort/sage [OR, 3.1; 95% CI, 1.6 to 6.0], and ragweed [OR, 2.1; 95% CI, 1.2 to 3.8]). Among all children, STR to outdoor allergens was strongly associated with the extent of allergen sensitization. As an example, children sensitized to mixed grass pollen had 34.7 times higher odds of having at least four positive skin tests to other allergens than nonsensitized children (95% CI for OR, 15.6 to 77.0).Conclusions: Our findings suggest that Puerto Rican ethnicity is associated with an increased risk of sensitization to indoor and outdoor allergens among children with asthma, and that allergy skin testing should be performed more often as part of the management of asthma in African-American children and in Puerto Rican children in the United States.