Identification and quantification of bisphenol A and bisphenol B in polyvinylchloride and polycarbonate medical devices by gas chromatography with mass spectrometry
Identification and quantification of bisphenol A and bisphenol B in polyvinylchloride and polycarbonate medical devices by gas chromatography with mass spectrometry
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DOI：
10.1002/jssc.201500552
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发表时间：
2015-11-01
影响因子：
3.1
通讯作者：
Lempereur, Laurent
中科院分区：
文献类型：
--
作者：
Gimeno, Pascal;Spinau, Coline;Lempereur, Laurent
建立了聚氯乙烯医疗器械中14种邻苯二甲酸酯和5种非邻苯二甲酸酯增塑剂的气相色谱-质谱法。为了测定聚氯乙烯样品中可能存在的增塑剂以外的双酚A和B，将以前的方法扩展到对这些额外的潜在内分泌干扰物的测定。此外，由于聚碳酸酯样品中也存在双酚A，因此对聚氯乙烯样品所用的方法用于聚碳酸酯医疗器械中双酚A和B的测定进行了测试和验证。在交联型5%苯基/95%二甲基聚硅氧烷毛细管柱上，利用温度梯度分离了所有化合物，包括双酚A和B。对于这两种塑料，样品在四氢呋喃中溶解，然后通过添加乙醇沉淀塑料。结果表明，聚碳酸酯样品的双酚A残留量为0.6%至0.8%，聚氯乙烯样品的双酚A残留量小于或等于5 ppm。在测试的样品中未检测到双酚B。对于双酚A和B，添加聚氯乙烯或聚碳酸酯样品的平均回收率为87%至108%，符合内部规范(80%至110%)。
A gas chromatography with mass spectrometry method has already been developed and published for the identification and quantification of 14 phthalates and five nonphthalate plasticizers in polyvinylchloride medical devices. In order to assay, in addition to plasticizers, bisphenols A and B possibly present in polyvinylchloride samples, this previous method was extended to the assay of these additional potential endocrine disruptors. Furthermore, as bisphenol A could also be present in polycarbonate samples, the method used for the polyvinylchloride sample was tested and validated for the assay of bisphenols A and B in polycarbonate medical devices. The separation of all compounds, including bisphenols A and B, is obtained on a cross-linked 5%-phenyl/95%-dimethylpolysiloxane capillary column using a temperature gradient. For both plastics, samples are dissolved in tetrahydrofuran followed by a precipitation of the plastic by addition of ethanol. Results obtained point out residual bisphenol A amounts for polycarbonate samples ranging from 0.6 to 0.8% and for polyvinylchloride samples less or equal to 5 ppm. No bisphenol B was detected in the samples tested. For bisphenols A and B, mean recoveries obtained on spiked polyvinylchloride or polycarbonate sample preparations ranged from 87 to 108% in accordance with in-house specification (80-110%).