The AMPA receptors of auditory neurons
The AMPA receptors of auditory neurons
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DOI：
10.1016/s0378-5955(00)00122-2
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发表时间：
2000-09-01
期刊：
影响因子：
2.8
通讯作者：
Parks, TN
中科院分区：
文献类型：
--
作者：
Parks, TN
The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post-transcriptional modifications of these proteins through mRNA editing and alternative exon splicing. The present paper reviews the published evidence for (1) localization of mRNAs and immunoreactivity for GluRs 1-4 in the cochlea and subcortical central nervous system auditory pathways of mammals and birds, and (2) involvement of AMPA receptors in synaptic transmission in the auditory system. Recent biochemical and electrophysiological evidence concerning the specialized properties of AMPA receptors on brainstem auditory neurons is also reviewed, along with data concerning how these properties emerge during normal development. (C) 2000 Elsevier Science B.V. All rights reserved.
