Improved efficacy with maintained tolerability in the treatment of primary hypertension. Comparison between the felodipine-metoprolol combination tablet and monotherapy with enalapril
Improved efficacy with maintained tolerability in the treatment of primary hypertension. Comparison between the felodipine-metoprolol combination tablet and monotherapy with enalapril
复制标题
DOI：
10.1038/sj.jhh.1000724
复制
发表时间：
1999-01-01
影响因子：
2.7
通讯作者：
Andersson, OK
中科院分区：
文献类型：
--
作者：
Andersson, OK
在这项多中心、双盲、平行组研究中，120名轻中度原发性高血压门诊患者在4周的单盲安慰剂运行期后被随机分配到每天一次的非洛地平-美托洛尔5/50 mg (Logimax（R)、Mobloc(R)、Astra）联合片剂或依那普利10 mg，每天一次。如果4周后血压（BP）仍处于次优控制状态（给药后24小时仰卧舒张压>90 mm Hg），则剂量加倍，再给药4周。8周后，非洛地平-美托洛尔降低仰卧位血压的效果明显优于依那普利（分别为19.7/12.0 mmHg和11.1/7.2 mmHg）。非洛地平-美托洛尔治疗组血压变化的平均差异为8.6/4.8 mm Hg （P = 0.001/P < 0.001）。非洛地平-美托洛尔的优势在站立BP中也有统计学上的显著差异。尽管依那普利组增加剂量的患者比例（61%）大于非洛地平-美托洛尔组（40%），但较少的依那普利治疗患者获得足够的血压控制(41% vs非洛地平-美托洛尔组（63%），P
In this multicentre, double-blind, parallel-group study, 120 out-patients with mild to moderate primary hypertension were randomised, after a 4-week single-blind placebo run-in period, to a combination tablet of felodipine-metoprolol 5/50 mg (Logimax(R), Mobloc(R), Astra) once daily or enalapril 10 mg once daily. If blood pressure (BP) remained suboptimally controlled after 4 weeks (supine diastolic BP >90 mm Hg 24-h post dose), the dose was doubled for a further 4 weeks. After 8 weeks felodipine-metoprolol reduced supine BP significantly more than enalapril (19.7/12.0 mmHg and 11.1/7.2 mm Hg, respectively). The mean differences in change in BP between treatments were 8.6/4.8 mm Hg in favour of felodipine-metoprolol (P = 0.001/P < 0.001). A statistically significant difference to the advantage of felodipine-metoprolol was also seen in standing BP. Even though the dose was increased in a larger proportion of patients in the enalapril group (61%) than in the felodipine-metoprolol group (40%), fewer enalapril-treated patients achieved adequate BP control (41% vs 63% on felodipine-metoprolol, P