VIPER: an advanced software package to support high-throughput LC-MS peptide identification
VIPER: an advanced software package to support high-throughput LC-MS peptide identification
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DOI：
10.1093/bioinformatics/btm281
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发表时间：
2007-08-01
期刊：
影响因子：
5.8
通讯作者：
Smith, Richard D.
中科院分区：
文献类型：
--
作者：
Monroe, Matthew E.;Tolic, Nikola;Smith, Richard D.
精确质量和时间（AMT）标签方法通过结合多个数据集和仪器类型生成的信息，用于分析大规模实验。VIPER软件包是数据处理管道的关键组件之一，并实现自动算法来发现LC-MS特征，将这些LC-MS特征与先前在LC-MS/MS分析中鉴定的肽数据库进行比对和匹配，并鉴定和定量同位素标记的肽对。
The accurate mass and time (AMT) tag approach is used for analysis of large scale experiments by combining information generated over multiple datasets and instrument types. The VIPER software package is one of the key components of the data processing pipeline and implements automated algorithms to discover LC-MS features, align and match these LC-MS features to a database of peptides previously identified in LC-MS/MS analyses, and identify and quantify pairs of isotopically labeled peptides.