Diagnosis and Treatment of Ovarian Cancer
Diagnosis and Treatment of Ovarian Cancer
复制标题
DOI：
10.1016/j.hoc.2018.07.010
复制
发表时间：
2018-12-01
影响因子：
2.4
通讯作者：
Edwards, Robert P.
中科院分区：
文献类型：
--
作者：
Orr, Brian;Edwards, Robert P.
上皮性卵巢癌典型的表现为不明原因的持续性胃肠道症状、泌尿系症状或非急性腹部/盆腔症状(腹胀、早饱、不适)。最终，盆腔检查或成像确定附件肿块通常伴有晚期腹膜播散。治疗包括积极的细胞减少性手术结合铂和紫杉烷化疗。在过去的20年里，最佳的切除以及化疗的方式和时机都发生了变化。作者回顾了卵巢上皮癌的初步诊断和治疗，并提供了可用的数据和建议，以指导在卵巢上皮癌的一线治疗中何时使用新辅助化疗、腹膜内化疗、HIPEC化疗、剂量密集化疗和维持化疗。
Epithelial ovarian cancer classically presents with vague persistent gastrointestinal, urologic, or nonacute abdominal/pelvic symptoms (bloating, early satiety, discomfort). Ultimately, a pelvic examination or imaging identifies an adnexal mass typically with accompanied advanced peritoneal dissemination. Management involves aggressive cytoreductive surgery in combination with platinum and taxane chemotherapy. Over the last 20 years, optimal resection and mode and timing of chemotherapy have evolved. The authors review the initial diagnosis and management and present the available data and recommendations to guide the decision tree of when to use neoadjuvant, intraperitoneal, HIPEC, dose-dense, and maintenance chemotherapy in the front-line treatment of epithelial ovarian cancer.