SUBSTANCE-P RELEASE FROM SPINAL-CORD SLICES BY CAPSAICIN
SUBSTANCE-P RELEASE FROM SPINAL-CORD SLICES BY CAPSAICIN
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DOI：
10.1016/0024-3205(79)90558-7
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发表时间：
1979-01-01
期刊：
影响因子：
6.1
通讯作者：
LEMBECK, F
中科院分区：
文献类型：
--
作者：
GAMSE, R;MOLNAR, A;LEMBECK, F
本文观察了大鼠下丘脑、黑质和脊髓切片P物质（SP）的释放。与47 mM K相比，辣椒素仅诱导脊髓切片释放SP。SP释放不被10-6 M河豚毒素减少，但被含有3 mM乙二醇双（β-氨基）的无Ca 2+培养基消除。氨基乙醚）N，N-四乙酸（EGTA）。辣椒素诱导的SP释放呈剂量依赖性，并表现出快速耐受性。辣椒素释放SP的能力支持SP参与疼痛传递和神经源性血浆外渗的假设。
The release of substance P (SP) from slices of hypothalamus, substantia nigra and spinal cord of the rat was studied. In contrast to 47 mM K, capsaicin induced SP release from spinal cord slices only. The SP release was not reduced by 10-6 M tetrodotoxin but was abolished by a Ca2+ free medium-containing 3 mM ethylene glycol bis-(.beta.-aminoethyl ether) N,N-tetraacetic acid (EGTA). Capsaicin induced SP release was dose-dependent and exhibited tachyphylaxis. The ability of capsaicin to release SP supports the hypothesis that SP is involved in pain transmission and in neurogenic plasma extravasation.