The human inferior parietal lobule in stereotaxic space
The human inferior parietal lobule in stereotaxic space
复制标题
DOI：
10.1007/s00429-008-0195-z
复制
发表时间：
2008-08-01
影响因子：
3.1
通讯作者：
Amunts, Katrin
中科院分区：
文献类型：
--
作者：
Caspers, Svenja;Eickhoff, Simon B.;Amunts, Katrin
近期，有人提出了人类顶下小叶（IPL）的一种新的细胞构筑图，其中顶下小叶由七个细胞构筑上不同的区域组成（卡斯帕斯等人，《神经影像学》33(2): 430 - 448, 2006）。本研究的目的是探究这些顶下小叶区域变异性的不同方面。作为变异性的一个方面，我们分析了这些区域边界的定位与宏观解剖标志之间的地形关系。尽管五个区域位于缘上回表面，两个位于角回，但通过宏观解剖无法可靠地检测出它们的边界。为了解释这些区域在立体定位空间中大小和范围的变异性，已为每个顶下小叶区域计算了细胞构筑概率图。基于细胞构筑区域的体积，对半球和性别相关的差异进行了研究。对于其中一个区域，即PFcm区，发现体积存在显著的性别差异，男性的体积大于女性；这种差异超过了全脑体积的性别差异。变异性和体积不对称的不同方面可能是顶下小叶中一些众所周知的功能不对称的基础，例如在分析空间注意或运动注意以及规划的功能性磁共振成像实验中所观察到的情况。七个顶下小叶区域的细胞构筑概率图提供了一个可靠的解剖学参考，并为人类顶下小叶进一步的结构 - 功能研究开辟了新的视角。
Recently, a new cytoarchitectonic map of the human inferior parietal lobule (IPL) has been proposed, with the IPL consisting of seven cytoarchitectonically distinct areas (Caspers et al. in Neuroimage 33( 2): 430-448, 2006). The aim of the present study was to investigate the different aspects of variability of these IPL areas. As one aspect of variability, we analysed the topographical relationship between the localisation of the borders of the areas and macroanatomical landmarks. Although five areas occupy the surface supramarginal gyrus and two the angular gyrus, their borders cannot be reliably detected by means of macroanatomy. To account for variability in size and extent of the areas in stereotaxic space, cytoarchitectonic probabilistic maps have been calculated for each IPL area. Hemisphere- and gender-related differences have been investigated on basis of volumes of cytoarchitectonic areas. For one of them, area PFcm, a significant gender difference in volume was found with males having larger volumes than females; this difference exceeds that of gender differences in total brain volume. The different aspects of variability and volumetric asymmetry may underlie some of the well-known functional asymmetries in the IPL, observed, for example during fMRI experiments analysing spatial attention or motor attention, and planning. The cytoarchitectonic probabilistic maps of the seven IPL areas provide a robust anatomical reference and open new perspectives for further structure-function investigations of the human IPL.