Cortical Regulation During the Early Stage of Initiation of Voluntary Swallowing in Humans
Cortical Regulation During the Early Stage of Initiation of Voluntary Swallowing in Humans
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DOI：
10.1007/s00455-003-0509-5
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发表时间：
2003
期刊：
影响因子：
2.6
通讯作者：
Yutaka Watanabe;S. Abe;T. Ishikawa;Yoshiaki Yamada;G. Yamane
中科院分区：
文献类型：
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作者：
Yutaka Watanabe;S. Abe;T. Ishikawa;Yoshiaki Yamada;G. Yamane
本研究的目的是利用脑磁图(MEG)揭示参与人类主动吞咽的皮质区域之间的时空关系。作为一项控制任务，研究人员也使用相同的技术对纯粹自愿的手指伸展运动进行了研究。在右侧舌骨上肌肌电开始前，吞咽相关活动广泛分布于2000ms，而手指相关活动则出现在记录的后期。扣带回、脑岛和额叶下回是吞咽前的主要活跃部位。这些大脑皮层的基因位点与之前人类大脑图谱研究的结果相吻合，这些研究探讨了控制吞咽的大脑机制。扣带回皮质的激活是在吞咽的早期阶段记录的，可能与对食物可以安全吞咽的认知过程有关。在吞咽开始之前，脑岛的激活持续了很长时间。这表明，吞咽前脑岛的长期激活对吞咽的启动是必不可少的。
The aim of the present study was to reveal the spatiotemporal relations among cortical regions involved in the initiation of voluntary swallowing in humans using magnetoencephalography (MEG). As a control task, finger extension movement, which is purely voluntary, was also investigated using the same techniques. The swallowing-related activity was distributed widely for 2000 ms before the electromyogram onset of the right suprahyoid muscle; however, the finger-related activity occurred in the late stage of the recording. The cingulate cortex, the insula, and the inferior frontal gyrus were the main loci active prior to swallowing. These cortical loci coincide with those suggested by previous human brain mapping studies that investigated the brain mechanism which controls swallowing. Activation in the cingulate cortex was registered in the early stage of swallowing and could be related to the cognitive process regarding the food being safe to swallow. The activation in the insula lasted for a long time before the initiation of swallowing. This suggests that the long-lasting activation in the insula prior to swallowing is essential for the initiation of swallowing.