TRANSFORMATION LINKED DECREASE OF PYRUVATE-DEHYDROGENASE COMPLEX IN HUMAN EPIDERMIS
TRANSFORMATION LINKED DECREASE OF PYRUVATE-DEHYDROGENASE COMPLEX IN HUMAN EPIDERMIS
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DOI：
10.1016/0304-3835(94)90281-x
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发表时间：
1994-10-14
期刊：
影响因子：
9.7
通讯作者：
PASQUINI, A
中科院分区：
文献类型：
--
作者：
EBOLI, ML;PASQUINI, A
表皮具有癌细胞特有的糖酵解特征。丙酮酸脱氢酶复合物的活性（PDHa）和总（PDHt）的形式，已被研究和比较，在表皮和表皮癌从人的来源。在正常和肿瘤组织中发现低或不可检测的PDHa。PDHt在人类表皮中在生命的第二个和第七个十年之间没有变化，但在肿瘤转化后急剧下降（表皮和表皮癌分别为0.107和0.026单位/g新鲜组织）。由于PDH在线粒体碳水化合物代谢中起关键作用，在肿瘤中发现的总酶能力的降低表明不同的机制调节PDK表达，进而调节表皮和癌细胞的糖酵解机制。
Epidermis exhibits glycolytic features peculiar to cancer cells. The activity of pyruvate dehydrogenase complex, both active (PDHa) and total (PDHt) forms, has been investigated and compared in epidermis and epidermal carcinomas from human source. Low or undetectable PDHa is found in either normal and neoplastic tissue. PDHt is unchanged in human epidermis between the second and seventh decades of life but is dramatically decreased following neoplastic transformation (0.107 and 0.026 units/g fresh tissue for epidermis and epidermal carcinoma, respectively). As PDH plays a key role in mitochondrial carbohydrate metabolism, the decrease of total enzymic capacity found in tumors suggest that different mechanisms regulate PDK expression and, in turn, glycolytic mechanisms of epidermis and cancer cells.