Acute ischemic stroke lesion measurement on diffusion-weighted imaging--important considerations in designing acute stroke trials with magnetic resonance imaging.
Acute ischemic stroke lesion measurement on diffusion-weighted imaging--important considerations in designing acute stroke trials with magnetic resonance imaging.
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DOI：
10.1016/j.jstrokecerebrovasdis.2006.11.003
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发表时间：
2007-03-01
期刊：
影响因子：
--
通讯作者：
Dennis, Martin S
中科院分区：
文献类型：
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作者：
Rivers, Carly S;Wardlaw, Joanna M;Dennis, Martin S
背景：在急性缺血性卒中中，磁共振弥散加权成像(DWI)越来越多地被用于临床试验或常规实践中选择纳入或作为替代结果标志的患者。目前尚不清楚哪些因素可能会影响DWI病变大小的测量。我们检查了可能影响DWI病变测量的形态因素。方法：在卒中后24小时内获得的DWI上，我们根据DWI的表现(单发或多灶性；边缘清楚或模糊)、病变大小(5 cm(3))和成像时间(
BACKGROUND: In acute ischemic stroke, magnetic resonance diffusion-weighted imaging (DWI) is increasingly used to select patients for inclusion or as a surrogate outcome marker in clinical trials, or in routine practice. Little is known of what factors might affect DWI lesion size measurement. We examined morphologic factors that might affect DWI lesion measurement.METHODS: On DWI obtained less than 24 hours after stroke, we categorized lesions according to DWI appearance (solitary or multifocal; well-defined or ill-defined edges), lesion size (5 cm(3)), and time to imaging (