Association between the epidermal growth factor rs4444903 G/G genotype and advanced fibrosis at a young age in chronic hepatitis C
Association between the epidermal growth factor rs4444903 G/G genotype and advanced fibrosis at a young age in chronic hepatitis C
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DOI：
10.1016/j.cyto.2011.10.018
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发表时间：
2012-01-01
期刊：
影响因子：
3.8
通讯作者：
Toniutto, Pierluigi
中科院分区：
文献类型：
--
作者：
Falleti, Edmondo;Cmet, Sara;Toniutto, Pierluigi
背景资料：表皮生长因子（EGF）rs 4444903 A > G多态性与肝癌的发生有关，肝癌通常会使病毒性肝硬化复杂化;然而，这种多态性是否可能与慢性病毒性肝炎的纤维化进展有关尚不清楚。本研究旨在评估rs 4444903 A > G多态性在慢性丙型肝炎病毒感染患者中的等位基因频率和基因型频率，并确定该多态性是否可能是慢性丙型肝炎病毒感染患者肝纤维化程度的独立预测因子。（211例肝硬化）; 528例转诊诊断和治疗慢性丙型肝炎，117例因HCV相关终末期肝病接受移植。428名健康志愿者作为对照组。结果：HCV慢性感染者EGF rs 4444903基因A > G多态性基因型频率分别为：A/A = 227（35.3%），A/G = 328（50.9%），G/G = 90（14.8%）。发现Ishak分期评分2的患者之间的基因型频率不同（A/A = 110，A/G = 171，G/G = 56，p = 0.038）。在年轻患者中检测到阶段评分增加与EGF基因型之间的高度显著线性关系（A/A：2.02 +/- 0.18，A/G：2.55 +/- 0.17，G/G：3.00 +/- 0.32，p = 0.008）。然而，在老年患者中，分期评分与EGF基因型之间没有显著相关性（A/A：3.79 +/- 0.19，A/G：3.64 +/- 0.15，G/G：3.98 +/- 0.30 p = 0.579）。EGF rs 4444903 A > G多态性可能促进白人慢性丙型肝炎患者的肝纤维化进展，特别是在年轻患者中。(C)2011爱思唯尔有限公司保留所有权利。
Background: The epidermal growth factor (EGF) rs4444903 A > G polymorphism has been associated with the development of liver cancer, which commonly complicates cirrhosis of viral origin; however, whether this polymorphism might be associated with fibrosis progression in chronic viral hepatitis is unknown. The present study was performed to assess the allelic and genotypic frequencies of the rs4444903 A > G polymorphism in patients with chronic hepatitis C virus HCV infection and to ascertain whether this polymorphism might be an independent predictor of the degree of fibrosis.Methods: An RFLP-PCR technique was used to genotype 645 patients (211 with cirrhosis); 528 were referred for the diagnosis and treatment of chronic hepatitis C, and 117 were transplanted for HCV-related end stage liver disease. A group of 428 healthy subjects served as a control. All the subjects were of Caucasian ethnicity.Results: The EGF rs4444903 A > G polymorphism genotype frequencies in HCV chronic infected patients were as follows: A/A = 227 (35.3%), A/G = 328 (50.9%), and G/G = 90 (14.8%). Genotype frequencies were found to differ between patients with an Ishak staging score 2 (A/A = 110, A/G = 171, G/G = 56, p = 0.038). A highly significant linear relationship between increasing stage scores and EGF genotype was detected in younger patients (A/A: 2.02 +/- 0.18, A/G: 2.55 +/- 0.17, G/G: 3.00 +/- 0.32, p = 0.008). However, no significant association was detected between the stage score and EGF genotype in older patients (A/A: 3.79 +/- 0.19, A/G: 3.64 +/- 0.15, G/G: 3.98 +/- 0.30 p = 0.579).Conclusions: The EGF rs4444903 A > G polymorphism may facilitate liver fibrosis progression in Caucasian patients with chronic hepatitis C, especially in younger patients. (C) 2011 Elsevier Ltd. All rights reserved.