Self-Organization in Living Cells: Networks of Protein Machines and Nonequilibrium Soft Matter
Self-Organization in Living Cells: Networks of Protein Machines and Nonequilibrium Soft Matter
复制标题
活细胞中的自组织：蛋白质机器和非平衡软物质的网络
DOI：
10.1023/a:1021247024192
复制
发表时间：
2002
影响因子：
1.8
通讯作者：
Benno Hess
中科院分区：
文献类型：
--
作者：
Alexander S. Mikhailov;Benno Hess
活细胞内的微观自组织现象不应该仅仅代表宏观系统中自组织的简化副本。一个细胞由活跃的蛋白质机器组成，这些机器通过在细胞质中扩散的小分子进行通信。机器周期的相互同步可以在这样的网络中自发地发展-一种类似于相干激光产生的效果。另一方面，生物软物质中的反应、扩散和相变之间的相互作用可能导致形成静止或移动的非平衡纳米结构。
Microscopic self-organization phenomena inside a living cell should not represent merely a reduced copy of self-organization in macroscopic systems. A cell is populated by active protein machines that communicate via small molecules diffusing through the cytoplasm. Mutual synchronization of machine cycles can spontaneously develop in such networks – an effect which is similar to coherent laser generation. On the other hand, an interplay between reactions, diffusion and phase transitions in biological soft matter may lead to the formation of stationary or traveling nonequilibrium nanoscale structures.