Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale
Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale
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DOI：
10.1016/j.jalz.2018.06.1353
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发表时间：
2018-12-01
影响因子：
14
通讯作者：
Devous, Michael D., Sr.
中科院分区：
文献类型：
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作者：
Navitsky, Michael;Joshi, Abhinay D.;Devous, Michael D., Sr.
简介：Klunk等。最近提出了一种方法的标准化定量淀粉样蛋白负荷从正电子发射断层扫描到一个共同的Centiloid规模，我们已经应用该方法florbetapir.Methods：Florbetapir和匹兹堡化合物B扫描，获得了46个混合临床表现的主题在18 +/- 20天。对于标准Centiloid（R-2 = 0.894）和Avid（R-2 = 0.901）感兴趣体积（VOI），Florbetapir和匹兹堡化合物B皮质标准化摄取值比值（SUVr）值具有良好的相关性。应用Klunk等人的方法，首先从使用标准Centiloid VOI获得的florbetapir SUVr值到Centiloids，然后从Avid VOI（Joshi等人）结果：将florbetapir SUVr从Avid VOI转化为Centiloid标度的方程如下：Florbetapir Centiloids = 183 X SUVr（Avid）-177。在尸检证实的数据中，区分神经病理学证实的无或稀疏与中度至频繁斑块的阈值为24.1 Centiloids.Discussion：这些发现可能允许改进的示踪剂非依赖性淀粉样蛋白定量。(C)2018由Elsevier Inc.出版代表老年痴呆症协会
Introduction: Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir.Methods: Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 +/- 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R-2 = 0.894) and Avid (R-2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids.Results: The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 X SUVr(Avid) - 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy-confirmed data is 24.1 Centiloids.Discussion: These findings may allow improved tracer-independent amyloid quantitation. (C) 2018 Published by Elsevier Inc. on behalf of the Alzheimer's Association.