n-3 polyunsaturated fatty acids and cancer.
n-3 polyunsaturated fatty acids and cancer.
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DOI：
10.1097/00075197-199903000-00005
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发表时间：
1999-03-01
影响因子：
3.1
通讯作者：
Bougnoux, P
中科院分区：
文献类型：
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作者：
Bougnoux, P
N-3多不饱和脂肪酸是一种很有前途的分子，在癌症预防和加强癌症治疗方面具有广阔的应用前景。最近的研究强调了它们与其他食物成分相互作用的重要性。它们对肿瘤生长的影响取决于n-6多不饱和脂肪酸和抗氧化剂的背景水平，这可能解释了以前在实验致癌方面不一致的结果。认识到脂质过氧化在多不饱和脂肪酸的抗肿瘤作用中的作用，这在各种体外或体内系统中都很明显，这是该领域的一个重大进展。因此，在涉及氧化应激的情况下，n-3多不饱和脂肪酸似乎是脂质过氧化的良好底物，例如在治疗癌症的几种细胞毒剂的作用中。
n-3 Polyunsaturated fatty acids are promising molecules in cancer prevention and the potentiation of cancer treatment. Recent studies have highlighted the importance of their interactions with other food components. Their effects on tumor growth depend upon background levels of n-6 polyunsaturated fatty acids and antioxidants, and this could account for previously inconsistent results in experimental carcinogenesis. Recognition of the role of lipoperoxidation in the anti-tumor effects of polyunsaturated fatty acids, which is apparent in a variety of in-vitro or in-vivo systems, has been a major advance in the field. Consequently, n-3 polyunsaturated fatty acids appear to be excellent substrates for lipid peroxidation in situations where an oxidative stress is involved, such as in the action of several cytotoxic agents in the treatment of cancer.