Prognostic Value of Metabolic and Volumetric Parameters of Preoperative FDG-PET/CT in Patients With Resectable Pancreatic Cancer.
Prognostic Value of Metabolic and Volumetric Parameters of Preoperative FDG-PET/CT in Patients With Resectable Pancreatic Cancer.
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DOI：
10.1097/md.0000000000003686
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发表时间：
2016-05
期刊：
影响因子：
1.6
通讯作者：
Lee DS
中科院分区：
文献类型：
--
作者：
Im HJ;Oo S;Jung W;Jang JY;Kim SW;Cheon GJ;Kang KW;Chung JK;Kim EE;Lee DS
在本研究中，我们旨在评估18F-脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)测量的代谢和体积参数在可切除胰腺癌患者中的预后价值。对51例经FDG-PET/CT和根治性手术治疗的可切除胰腺癌患者进行回顾性研究。通过FDG-PET/CT测量最大标准摄取值(SUVmax)、代谢性肿瘤体积(MTV)和总病变糖酵解(TLG)。评价FDG-PET/CT与临床病理参数的关系。通过单因素和多因素分析评估FDG-PET/CT和临床病理参数对无复发生存期(RFS)和总生存期(OS)的预后价值。对51例入选患者进行了中位时间21个月( ± SD：23 ± 16个月，范围1-78个月)的随访，33例(65%)复发，30例(59%)死亡。SUVmax、MTV和TLG与肿瘤转移(TNM)分期和有无淋巴结转移有关。MTV和TLG与淋巴血管侵犯相关，而SUVmax与淋巴血管侵犯无关。在单变量分析中，SUVmax、MTV和TLG与RFS和OS相关。单因素分析显示，淋巴结转移和TNM分期与OS有关。多因素分析显示，MTV和TLG是影响RFS和OS的独立预后因素。SUVmax是OS的独立预后因素，但不是RFS的独立预后因素。代谢性肿瘤体积和TLG独立预测可切除胰腺癌的RFS和OS。SUVmax是OS的独立影响因素，而不是RFS的独立影响因素。
In this study, we aimed to evaluate prognostic value of metabolic and volumetric parameters measured from 18F fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in patients with resectable pancreatic cancer. Fifty-one patients with resectable pancreatic cancer who underwent FDG-PET/CT and curative operation were retrospectively enrolled. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured from FDG-PET/CT. Association between FDG-PET/CT and clinicopathologic parameters was evaluated. The prognostic values of the FDG-PET/CT and clinicopathologic parameters for recurrence-free survival (RFS) and overall survival (OS) were assessed by univariate and multivariate analyses. The 51 enrolled patients were followed up for a median of 21 months (mean ± SD: 23 ± 16 months, range: 1–78 months) with 33 (65%) recurrences and 30 (59%) deaths during the period. SUVmax, MTV, and TLG were associated with Tumor node metastasis (TNM) stage and presence of lymph node metastasis. MTV and TLG were associated with presence of lymphovascular invasion, whereas SUVmax was not. On the univariate analysis, SUVmax, MTV, and TLG were associated with RFS and OS. Also, lymph node metastasis and TNM stage were associated with OS on the univariate analysis. On multivariate analysis, MTV and TLG were independent prognostic factors for RFS and OS. SUVmax was an independent prognostic factor for OS, but not for RFS. Metabolic tumor volume and TLG were independently predictive of RFS and OS in resectable pancreatic cancer. SUVmax was an independent factor for OS, but not for RFS.