Association of Cognitive Function with Albuminuria and eGFR in the General Population
Association of Cognitive Function with Albuminuria and eGFR in the General Population
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DOI：
10.2215/cjn.05530610
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发表时间：
2011-06-01
影响因子：
9.8
通讯作者：
Gansevoort, Ron T.
中科院分区：
文献类型：
--
作者：
Joosten, Hanneke;Izaks, Gerbrand J.;Gansevoort, Ron T.
背景和目的最近的研究发现，认知功能与蛋白尿或估计的肾小球滤过率(EGFR)之间存在不同的相关性。大多数研究仅限于老年人，或者没有将这两个肾脏变量考虑在内。因此，这项研究分析了35至82岁社区居民的认知功能与蛋白尿和EGFR的关系。设计、设置、参与者和测量：这是一项横断面研究，包括4095名肾脏和血管终末期疾病预防(PREVEND)研究的参与者。结果白蛋白尿30 mg/24 h的患病率分别为54%、31%和15%。平均EGFR(+/-SD)为79+/-15ml/min/1.73m(2)。由于蛋白尿和年龄之间的相互作用，分析是按年龄三分位数进行的。经多因素调整后，蛋白尿<30 mg/24 h与最年轻三联体的RFFT评分降低相关(B5.3；95%CI，-0.6~-9.2；P=0.05)，而与EGFR无关。此外，在RFFT测量前，最年轻的白蛋白增多组(5-15和-GT；15 mg/24 h)的平均RFFT得分低于稳定白蛋白尿组：平均差值分别为-4.9(P=0.3)和-6.7(P=0.03)。结论在该社区队列中，白蛋白尿升高与认知功能下降有关，在年轻人中，但在老年人中没有。EGFR与认知功能之间没有关联。临床J am Soc肾病6：1400-1409,2011。DOI：10.2215/QN.05530610
Background and objectives Recent studies found different associations of cognitive function with albuminuria or estimated GFR (eGFR). Most studies were limited to the elderly or did not take both renal variables into account. Therefore, this study analyzed the association of cognitive function with albuminuria and eGFR in community-dwelling persons aged 35 to 82 years.Design, setting, participants, & measurements This was a cross-sectional study comprising 4095 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Cognitive function, measured with the Ruff Figural Fluency Test (RFFT), was treated as the dependent variable, and albuminuria and eGFR were treated as independent variables.Results The prevalence of albuminuria = 30 mg/24 h was 54%, 31%, and 15%, respectively. Mean eGFR (+/- SD) was 79 +/- 15 ml/min per 1.73 m(2). Because of interaction between albuminuria and age, analyses were performed per age tertile. After multivariate adjustment, albuminuria >= 30 mg/24 h, but not eGFR, was associated with lower RFFT score in the youngest tertile (B 5.3; 95% CI, -0.6 to -9.2; P = 0.05), but not in older tertiles. Moreover, subjects in the youngest tertile with increasing albuminaria (5-15 and >15 mg/24 h) before RFFT measurement had lower mean RFFT scores than subjects with stable albuminuria: mean difference -4.9 (P = 0.3) and -6.7 (P = 0.03), respectively.Conclusions In this community-based cohort, elevated albuminuria was associated with worse cognitive function in young but not in old persons. There was no association of eGFR with cognitive function. Clin J Am Soc Nephrol 6: 1400-1409, 2011. doi: 10.2215/QN.05530610