T Cell Reactivity againstMycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections
T Cell Reactivity againstMycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections
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DOI：
10.1155/2011/640309
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发表时间：
2011-01-01
影响因子：
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通讯作者：
Huygen, Kris
中科院分区：
文献类型：
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作者：
Launois, Pascal;Drowart, Annie;Huygen, Kris
分枝菌酰转移酶抗原85复合物是来自分枝杆菌培养滤液的主要分泌蛋白家族，在大多数HIV阴性、结核菌素阳性的潜伏性分枝杆菌感染的志愿者中显示出强大的T细胞刺激特性。结核病感染和艾滋病毒阴性的结核病患者只有微弱的反应。在这里，我们分析了T细胞对PPD和Ag 85在HIV感染的个人，没有或有结核病的临床症状，并在艾滋病患者的非结核分枝杆菌引起的疾病。HIV阴性和HIV阳性结核菌素阳性志愿者对PPD的反应无显著差异，而HIV阳性（CDC-A和CDC-B）组对Ag 85的反应显著降低。结核病患者对Ag 85表现出低T细胞反应性，与HIV感染无关，最后患有NTM感染的AIDS患者对Ag 85完全无反应。对12名HIV阳性结核菌素阳性个体进行了为期一年的随访，结果表明，临床结核病患者对Ag 85的反应性降低，突出了这种抗原的保护潜力。
The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M. tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen.