Brain activity during episodic retrieval of autobiographical and laboratory events: An fMRI study using a novel photo paradigm
Brain activity during episodic retrieval of autobiographical and laboratory events: An fMRI study using a novel photo paradigm
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DOI：
10.1162/0898929042568578
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发表时间：
2004-11-01
影响因子：
3.2
通讯作者：
Rubin, DC
中科院分区：
文献类型：
--
作者：
Cabeza, R;Prince, SE;Rubin, DC
情景记忆提取的功能性神经影像学研究通常在参与者回忆在实验室中遇到的项目（“受控实验室条件”）或他们自己生活中的事件（“开放式自传体条件”）时测量大脑活动。这些条件之间激活的差异可能反映了提取过程、记忆久远程度、情感内容、提取成功、自我参照加工、视觉/空间记忆以及回忆之间的差异。为了阐明这些差异的本质，利用一种新颖的“照片范式”进行了一项功能性磁共振成像研究，该范式可以对自传体条件进行更好的控制，包括对提取准确性的测量。本科学生在指定的校园位置拍照（“受控自传体条件”），在实验室观看其他参与者拍摄的类似照片（受控实验室条件），然后在识别这两种照片时进行扫描。两种条件都激活了一个共同的情景记忆网络，该网络包括内侧颞叶和前额叶区域。与受控实验室条件相比，受控自传体条件在与自我参照加工（内侧前额叶皮质）、视觉/空间记忆（视觉和海马旁回区域）以及回忆（海马体）相关的区域引发了更强的活动。照片范式提供了一种在严格的实验控制下研究现实生活情景记忆的功能神经解剖学的方法。
Functional neuroimaging studies of episodic memory retrieval generally measure brain activity while participants remember items encountered in the laboratory ("controlled laboratory condition'') or events from their own life ("open autobiographical condition''). Differences in activation between these conditions may reflect differences in retrieval tween processes, memory remoteness, emotional content, retrieval success, self-referential processing, visual/spatial memory, and recollection. To clarify the nature of these differences, a functional MRI study was conducted using a novel "photo paradigm,'' which allows greater control over the autobiographical condition, including a measure of retrieval accuracy. graphical Undergraduate students took photos in specified campus locations ("controlled autobiographical condition''), viewed in the laboratory similar photos taken by other participants ( controlled laboratory condition), and were then scanned while recognizing the two kinds of photos. Both conditions activated a common episodic memory network that included medial temporal and prefrontal regions. Compared with the controlled laboratory condition, the controlled autobiographical condition elicited greater activity in regions associated with self-referential processing ( medial prefrontal cortex), visual/ spatial memory ( visual and parahippocampal regions), and recollection ( hippocampus). The photo paradigm provides a way of investigating the functional neuroanatomy of real-life episodic memory under rigorous experimental control.