Effects of bright light treatment on depression- and anxiety-like behaviors of diurnal rodents maintained on a short daylight schedule
Effects of bright light treatment on depression- and anxiety-like behaviors of diurnal rodents maintained on a short daylight schedule
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DOI：
10.1016/j.bbr.2009.03.005
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发表时间：
2009-08-12
影响因子：
2.7
通讯作者：
Kronfeld-Schor, Noga
中科院分区：
文献类型：
--
作者：
Ashkenazy, Tal;Einat, Haim;Kronfeld-Schor, Noga
昼夜节律和情感障碍之间可能存在的关系已被强烈暗示，但这种关系的生物学基础的理解需要利用适当的动物模型。大多数研究是在夜间活动的啮齿动物身上进行的，而夜间活动的动物的日光周期或褪黑激素水平的一些影响可能与日间活动的物种（包括人类）的影响有很大不同。最近的研究表明，昼夜肥胖沙鼠作为一个合适的模型动物研究昼夜机制参与情绪和焦虑障碍，特别是季节性情感障碍（SAD）。这些研究表明，沙鼠长期暴露于短日照（SD），或模拟短日照的褪黑激素方案，表现出焦虑和抑郁样行为。这些发现建立了模型的面效度和结构效度。本研究通过检测慢性SD大鼠的强光治疗效果来评估预测有效性。SD大鼠维持3周，每天1h，3000 lx光照，持续3周，“光照”后1h。（在光/暗循环的光阶段期间），并且在甜味溶液偏好测试（SSP）中测试它们的行为，高架十字迷宫（ESTA）和强迫游泳测试（FST），并与未处理的对照动物进行比较。结果表明，明亮的光处理减少焦虑样行为的焦虑和抑郁样行为的FST，但不SSP。实验结果表明，白天活动的沙鼠可能是SAD研究的理想动物。(C)2009爱思唯尔有限公司版权所有。
A possible relationship between circadian rhythms and affective disorders has been strongly implicated, but understanding of the biological basis of such a relationship demands the utilization of appropriate animal models. Most research is performed with nocturnal rodents while some of the effects of daylight cycles or melatonin levels in nocturnal animals may differ greatly from effects in diurnal species (including humans). Recent studies suggested the diurnal fat Sand rat as an appropriate model animal to study circadian mechanisms involvement in mood and anxiety disorders, especially seasonal affective disorder (SAD). These studies demonstrated that Sand rats chronically exposed to short daylight (SD), or to melatonin regimen mimicing short daylight, show anxiety- and depression-like behaviors. These findings established face and construct validity for the model. The present study evaluated predictive validity by testing the effects of bright light treatment in Sand rats exposed to chronic SD.Sand rats maintained on SD for 3 weeks were treated with 1 h daily 3000 Ix light for 3 weeks, 1 h after "lights on" (during the light phase of the light/dark cycle), and their behavior tested in the sweet solution preference test (SSP), elevated plus-maze (EPM) and forced swim test (FST) and compared with control animals without treatment. Results indicate that bright light treatment reduced anxiety-like behavior in the EPM and depression-like behavior in the FST but not SSP. It is suggested that the results support the possibility that the diurnal Sand rat might be a preferred model animal for the study of SAD. (C) 2009 Elsevier B.V. All rights reserved.