Synergic effect of copper-based metal-organic frameworks for highly efficient C-H activation of amidines
Synergic effect of copper-based metal-organic frameworks for highly efficient C-H activation of amidines
复制标题
铜基金属-有机骨架对脒高效C-H活化的协同作用
DOI：
10.1039/c7ra10682c
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发表时间：
2017
期刊：
影响因子：
3.9
通讯作者：
Liu Chun Sen
中科院分区：
文献类型：
--
作者：
Xu Fen;Kang Wei Fen;Wang Xiao Ning;Kou Hao Dong;Jin Zhen;Liu Chun Sen
为方便高效地合成苯并咪唑，研究了cu - mof催化取代脒的C-H功能化反应。更重要的是，这种转化与没有邻位取代基的芳基腈衍生的各种底物兼容。在无氧气氛或无特定基团的条件下，537-MOF是扩大反应范围、提高收率达96%的关键参数。重要的是，这一策略也为进一步利用mof作为具有挑战性的有机反应的催化剂提供了许多机会。
A Cu–MOF-catalyzed C–H functionalization of substituted amidines was developed for the facile and efficient synthesis of benzimidazoles. More importantly, this transformation is compatible with various substrates derived from aryl nitriles without ortho substituents. Under reaction conditions devoid of O2 atmosphere or specific groups, 537-MOF has been revealed as a key parameter for expanding the reaction scope and increasing the yield up to 96%. Importantly, this strategy also provides numerous opportunities for further utilization of MOFs as catalysts for challenging organic reactions.