Occurrence of surface IgM, IgD, and free light chains of human lymphocytes.
Occurrence of surface IgM, IgD, and free light chains of human lymphocytes.
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人淋巴细胞的表面IgM，IgD和游离光链的发生。
DOI：
10.1084/jem.139.2.451
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发表时间：
1974-02-01
影响因子：
15.3
通讯作者：
Kunkel, H G
中科院分区：
文献类型：
--
作者：
Fu, S M;Winchester, R J;Kunkel, H G
本文对慢性淋巴白血病（CLL）患者细胞的免疫球蛋白表面标记物进行了分析，以证实其单克隆b细胞特征。在大多数情况下，免疫荧光和血凝抑制均证实IgM和IgD同时存在于大多数淋巴细胞表面。然而，既有表面IgM无IgD的病例，也有IgD无IgM的病例。IgG和IgA均不存在。对轻链的研究表明，在给定的情况下，只有一类。除了结合轻链外，在大多数情况下，通过使用针对“自由链”决定因子的抗血清，很容易证明自由轻链。因此，CLL淋巴细胞表面的igg主要有三种类型：IgM、IgD和游离轻链。
An analysis was made of the immunoglobulin surface markers of the cells of patients with chronic lymphatic leukemia (CLL) in view of previous evidence of their monoclonal B-cell character. The simultaneous presence of IgM and IgD on the surface of the majority of lymphocytes was demonstrated by both immunofluorescence and hemagglutination inhibition in most cases. However, cases were observed with surface IgM without IgD as well as cases with IgD without IgM. IgG and IgA were absent. Studies of the light chains indicated only a single class in a given case. In addition to bound light chains, free light chains were readily demonstrated in most cases through the use of antisera specific for "free chain" determinants. It thus appeared that there are three major types of surface Ig on CLL lymphocytes, IgM, IgD, and free light chains.