Relationship Between Emotional Behavior in Mice and the Concentration of (+)-α-Santalol in the Brain
Relationship Between Emotional Behavior in Mice and the Concentration of (+)-α-Santalol in the Brain
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DOI：
10.1002/ptr.5372
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发表时间：
2015-08-01
影响因子：
7.2
通讯作者：
Koike, Kazuo
中科院分区：
文献类型：
--
作者：
Satou, Tadaaki;Ogawa, Yuko;Koike, Kazuo
我们以前曾报道过檀香油在小鼠中给药后发现抗焦虑样活性。在这份报告中，我们进一步研究了与吸入或腹腔注射（+）-檀香醇，檀香油的主要成分，除了检查是否药理学或神经转移负责这种行为的情绪行为。通过吸入或腹腔注射给予（+）-檀香醇后，我们使用高架迷宫试验评估了抗焦虑样和自主活动。我们还研究了情绪行为与（+）-檀香醇脑浓度之间的关系。（+）--檀香醇2L/L空气吸入或（+）--檀香醇0.03mL/kg（i. p.）局而腹腔注射（+）-檀香醇0.03mL/kg，小鼠在浸水应激24 h后，其自发活动明显减少。（+）--檀香醇0.03mL/kg（i. p.）局所观察到的（+）-檀香醇转移到大脑表明，该成分通过药理学转移起作用，并负责镇静作用，但不是抗焦虑样活性。版权所有（c）2015约翰威利父子有限公司
We previously reported finding anxiolytic-like activity for sandalwood oil after administration in mice. In this report, we further investigated the emotional behavior associated with inhaled or intraperitoneally administered (+)--santalol, the main component of sandalwood oil, in addition to examining whether pharmacological or neurological transfers are responsible for this behavior. After administration of (+)--santalol by inhalation or intraperitoneal injection, we assessed anxiolytic-like and locomotor activities using elevated-plus maze tests. We also examined the relationship between the emotional behavior and the (+)--santalol brain concentration. Anxiolytic-like activity was not observed immediately after administration or after water-immersion stress for 24h for either the (+)--santalol 2L/L air inhalation or the (+)--santalol 0.03mL/kg (i.p.) administration. However, mice administered (+)--santalol 0.03mL/kg intraperitoneally exhibited a significant decrease in the locomotor activity after exposure to water-immersion stress for 24h. The brain (+)--santalol concentration was 2.6 mu g/g tissue after (+)--santalol 0.03mL/kg (i.p.) administration. The observed shift of (+)--santalol to the brain suggests that this component acts via pharmacological transfer and is responsible for the sedative effect but not the anxiolytic-like activity. Copyright (c) 2015 John Wiley & Sons, Ltd.