Rate of bone loss is greater in young Mexican American men than women: the San Antonio Family Osteoporosis Study.
Rate of bone loss is greater in young Mexican American men than women: the San Antonio Family Osteoporosis Study.
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墨西哥裔美国年轻男性的骨质流失率高于女性：圣安东尼奥家庭骨质疏松症研究。
DOI：
10.1016/j.bone.2010.03.011
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发表时间：
2010
期刊：
影响因子：
4.1
通讯作者：
Mitchell,BraxtonD
中科院分区：
文献类型：
--
作者：
Shaffer,JohnR;Kammerer,CandaceM;Dressen,AmyS;Bruder,JanM;Bauer,RichardL;Mitchell,BraxtonD
关于成年早期骨质流失的进展情况以及男性和女性之间是否存在差异，人们知之甚少。作为圣安东尼奥家庭骨质疏松症研究的一部分，我们测试了男性或女性的骨矿物质密度 (BMD) 是否随时间变化，以及两性之间 BMD 变化率是否存在差异。通过双能 X 射线吸收仪在两个时间点（相隔 5.6 年）测量 115 名男性和 202 名绝经前女性（年龄 25 至 45 岁；墨西哥裔美国人血统）的股骨近端、脊柱、桡骨和全身的 BMD，从中计算 BMD 的年度百分比变化。基于可能性的方法用于测试 BMD 变化是否不同于零或男性和女性之间是否存在差异。在男性中，1/3 半径的 BMD 变化百分比显着大于零（即表明 BMD 增加；Bonferroni 调整后的 p<0.01），股骨颈、腰椎、桡骨远端和全身的 BMD 变化百分比小于零（即表明 BMD 损失；全部 p<0.01），而全髋部与零没有差异（p=0.24）。在女性中，全髋部、1/3 桡骨和全身的 BMD 变化百分比均大于零（全部 p<0.01），超远端半径小于零（p<0.01），股骨颈和腰椎的 BMD 变化百分比与零没有显着差异（两者均 p=1.0）。对于所有骨骼部位，男性的 BMD 下降幅度大于女性（或 BMD 的增长幅度较小）；无论是否对年龄、BMI 和 BMI 变化进行调整（均 p<0.05），均观察到了这一结果。这些结果表明，与年轻女性相比，年轻男性和女性的一些骨骼部位发生了显着的骨质流失，并且年轻男性的 BMD 损失发生得明显更快，或者 BMD 的增加发生得明显更慢。
Little is known about the progression of bone loss during young adulthood and whether it differs between men and women. As part of the San Antonio Family Osteoporosis Study we tested whether bone mineral density (BMD) changed over time in men or women, and whether the rate of BMD change differed between the sexes. BMD of the proximal femur, spine, radius, and whole body was measured in 115 men and 202 pre-menopausal women (ages 25 to 45years; Mexican American ancestry) by dual-energy x-ray absorptiometry at two time points (5.6years apart), from which annual percent change-in-BMD was calculated. Likelihood-based methods were used to test whether change-in-BMD differs from zero or differs between men and women. In men, percent change-in-BMD was significantly greater than zero for the 1/3 radius (i.e. indicating a gain of BMD; Bonferroni-adjusted p<0.01), less than zero for the femoral neck, lumbar spine, ultradistal radius, and whole body (i.e. indicating a loss of BMD; p<0.01 for all), and not different than zero for the total hip (p=0.24). In women, percent change-in-BMD was greater than zero for the total hip, 1/3 radius, and whole body (p<0.01 for all), less than zero for the ultradistal radius (p<0.01), and not significantly different than zero for the femoral neck and lumbar spine (p=1.0 for both). For all skeletal sites, men experienced greater decrease in BMD (or less increase in BMD) than women; this result was observed both with and without adjustment for age, BMI, and change-in-BMI (p<0.05 for all). These results suggest that significant bone loss occurs at some skeletal sites in young men and women, and that loss of BMD is occurring significantly faster, or gain of BMD is occurring significantly slower, in young men compared to young women.
影响因子：
9.8
作者：
Almasy, L;Blangero, J
通讯作者：
Blangero, J