Significance of pacemaker vs. non-pacemaker neurons in an excitatory rhythmic network.
Significance of pacemaker vs. non-pacemaker neurons in an excitatory rhythmic network.
复制标题
兴奋性节律网络中起搏器与非起搏器神经元的重要性。
DOI：
10.1109/iembs.2006.260511
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Butera,RobertJ
中科院分区：
文献类型：
--
作者：
Purvis,ListonK;Wright,TerrenceM;Smith,JeffreyC;Butera,RobertJ
This modeling study investigates the functional role of pacemaker neurons in generating stable rhythms in the pre-Botzinger complex, a subcircuit of the respiratory pattern-generating circuitry in mammals. While the presence of pacemakers within the network is without doubt, the percentage and significance of such pacemakers is still unresolved. Here we revisited earlier network simulations by varying the fraction of pacemaker and non-pacemaker neurons within the network, and quantifying the robustness of the input parameter space and range of frequencies output by the network. Stable network rhythms were possible even with no pacemakers. However, we found that a network of at least 50% pacemakers produced the greatest range of output frequencies and had the more robust input space
