Glycerophosphate/Acylglycerophosphate acyltransferases.
Glycerophosphate/Acylglycerophosphate acyltransferases.
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DOI：
10.3390/biology3040801
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发表时间：
2014-11-19
期刊：
影响因子：
4.2
通讯作者：
Sugiura T
中科院分区：
文献类型：
--
作者：
Yamashita A;Hayashi Y;Matsumoto N;Nemoto-Sasaki Y;Oka S;Tanikawa T;Sugiura T
酰基-CoA：甘油-3-磷酸酰基转移酶（GPAT）和酰基-CoA：1-酰基-甘油-3-磷酸酰基转移酶（AGPAT）参与三酰甘油（TAG）和甘油磷脂的从头合成。许多属于GPAT/AGPAT家族的酶最近已经被鉴定，并且已经提出了它们的生理或病理生理作用。GPAT/AGPAT在TAG合成和肥胖相关疾病中的作用通过这些疾病的致病基因的鉴定或遗传操作动物的分析来揭示。最近的研究表明，GPAT/AGPAT家族酶的某些异构体参与磷脂的脂肪酸重构。本文对GPAT/AGPAT的酶学性质及其在甘油脂代谢中的生理病理作用进行了综述和讨论。
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/pathological roles in the metabolism of glycerolipids have been described and discussed in this review.