Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive monitoring of MDMA in interstitial fluid
Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive monitoring of MDMA in interstitial fluid
复制标题
DOI：
10.1016/j.microc.2023.109257
复制
发表时间：
2023-08-27
影响因子：
4.8
通讯作者：
De Wael，Karolien
中科院分区：
文献类型：
--
作者：
Dragan，Ana-Maria;Parrilla，Marc;De Wael，Karolien
非法药物消费由于其日益蔓延和滥用以及对社会造成的消极后果，在全世界引起了极大的关注。例如，3,4-亚甲基二氧甲基苯丙胺（MDMA）是一种合成苯丙胺类物质，2020年全球有2000万人滥用。这种精神活性物质对人体有无数的影响，对消费者的健康是危险的。此外，MDMA已被用于治疗一些精神疾病。因此，开发可穿戴设备在生物体液中检测MDMA对于法医毒理学（例如，监测疑似或已知MDMA消费的患者）以及患者的治疗管理具有重要意义。在此，我们报告了一种基于空心微针（MN）阵列传感器的可穿戴电化学平台的开发，用于方波伏安法监测间隙液中的MDMA。首先，用导电浆料修饰MN阵列的孔，设计出具有三电极系统的MN贴片。随后，纳米材料功能化工作电极增强了MDMA检测。随后，分析参数在1至50µM的线性范围内的斜率为0.05µaµM−1，在人工间质液中的检测限为0.75µM。重要的是，对选择性、穿透能力、温度、可逆性和稳定性等关键参数进行了评估。总的来说，所获得的MN传感器表现出优异的分析性能，使其成为一种有希望的工具，用于在试用或治疗中的个体间质液中跟踪MDMA。
Illicit drug consumption constitutes a great concern worldwide due to its increased spread and abuse, and the negative consequences exerted on society. For instance, 3,4-methylenedioxymethamphetamine (MDMA), a synthetic amphetamine-type substance, was abused by 20 million people worldwide in 2020. This psychoactive substance exerts a myriad of effects on the human body being dangerous for the consumer’s health. Besides, MDMA has been used in the treatment of some psychiatric conditions. Therefore, the development of wearable devices for MDMA sensing in biological fluids is of great importance for forensic toxicology (e.g., monitoring of patients with suspected or known MDMA consumption) as well as for therapeutic management of patients. Herein, we report the development of a wearable electrochemical platform based on a hollow microneedle (MN) array sensor for the monitoring of MDMA in the interstitial fluid by square-wave voltammetry. First, the holes of the MN array were modified with conductive pastes to devise a MN patch with a three-electrode system. Subsequently, the functionalization of the working electrode with nanomaterials enhanced MDMA detection. Thereafter, analytical parameters were evaluated exhibiting a slope of 0.05 µA µM−1within a linear range from 1 to 50 µM and a limit of detection of 0.75 µM in artificial interstitial fluid. Importantly, critical parameters such as selectivity, piercing capability, temperature, reversibility and stability were assessed. Overall, the obtained MN sensor exhibited excellent analytical performance, making it a promising tool for MDMA tracking in interstitial fluid for individuals on probation or under therapeutic treatment.