Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine.
Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine.
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新生儿暴露于(±)-3,4-亚甲二氧基甲基苯丙胺的成年大鼠的神经元重组。
DOI：
10.1016/j.toxrep.2014.08.018
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发表时间：
2014
影响因子：
--
通讯作者：
Brown,RussellW
中科院分区：
文献类型：
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作者：
Williams,MichaelT;Skelton,MatthewR;Longacre,IanD;Huggins,KimberlyN;Maple,AmandaM;Vorhees,CharlesV;Brown,RussellW
在类似于人类妊娠后期的大脑生长期间，对大鼠进行MDMA治疗会导致神经化学和行为变化。大鼠出生后11-20天的MDMA会导致血清素减少，并导致空间和路线导航能力下降。在本实验中，我们研究了从P11到P20的MDMA （20 mg/kg，每天两次，间隔8 h）对神经元结构的影响。高尔基浸渍切片变化显著。在伏隔核，树突变短，棘变少，而在齿状回，树突长度变短，但棘变多，而在内嗅皮层，与生理盐水动物相比，MDMA动物的基底和顶端树突长度减少。数据显示，在发育性MDMA暴露后，神经元细胞结构的变化是持久的，并且在这些动物中观察到的与学习和记忆缺陷一致的区域。
The abuse of methylenedioxymethamphetamine (MDMA) during pregnancy is of concern. MDMA treatment of rats during a period of brain growth analogous to late human gestation leads to neurochemical and behavioral changes. MDMA from postnatal day (P)11–20 in rats produces reductions in serotonin and deficits in spatial and route-based navigation. In this experiment we examined the impact of MDMA from P11 to P20 (20 mg/kg twice daily, 8 h apart) on neuronal architecture. Golgi impregnated sections showed significant changes. In the nucleus accumbens, the dendrites were shorter with fewer spines, whereas in the dentate gyrus the dendritic length was decreased but with more spines, and for the entorhinal cortex, reductions in basilar and apical dendritic lengths in MDMA animals compared with saline animals were seen. The data show that neuronal cytoarchitectural changes are long-lasting following developmental MDMA exposure and are in regions consistent with the learning and memory deficits observed in such animals.