Regio- and Enantioselective Palladium-Catalyzed Asymmetric Allylation of N-Fluorenyl Trifluoromethyl Imine
Regio- and Enantioselective Palladium-Catalyzed Asymmetric Allylation of N-Fluorenyl Trifluoromethyl Imine
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N-芴基三氟甲基亚胺的区域选择性和对映选择性钯催化不对称烯丙基化
DOI：
10.1021/acs.orglett.0c01836
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Zhang Xia
中科院分区：
文献类型：
--
作者：
Wang Wei;Xiong Qin;Gong Liang;Wang Yingwei;Liu Jie;Lan Yu;Zhang Xia
公开了一种钯催化的N-芴基三氟甲基亚胺与乙酸烯丙酯的不对称烯丙基化反应。该方法提供了可扩展的和有效的途径，以高产率获得具有两个相邻立构中心和一个烯丙基的多取代的手性α-三氟甲基胺，具有优异的区域选择性、非对映选择性和对映选择性。重要的是，这种方法还提供了一个强大的战略，为两个区域异构体的产品和区域选择性的合成是由手性催化剂和光学活性底物控制。
A palladium-catalyzed asymmetric allylation ofN-fluorenyl trifluoromethyl imine with allylic acetates is disclosed. This method provides scalable and efficient access to polysubstituted chiral α-trifluoromethyl amines bearing two adjacent stereocenters and one allyl group in high yields with excellent regio-, diastereo-, and enantioselectivity. Importantly, this method also provides a powerful strategy for the synthesis of both regioisomeric products and the regioselectivity is controlled by the chiral catalysts and optically active substrates.