FUNCTION OF CIRCULATING ANTIBODY TO ACETYLCHOLINE-RECEPTOR IN MYASTHENIA-GRAVIS - INVESTIGATION BY PLASMA EXCHANGE
FUNCTION OF CIRCULATING ANTIBODY TO ACETYLCHOLINE-RECEPTOR IN MYASTHENIA-GRAVIS - INVESTIGATION BY PLASMA EXCHANGE
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DOI：
10.1212/wnl.28.3.266
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发表时间：
1978-01-01
期刊：
影响因子：
9.9
通讯作者：
WILSON, SG
中科院分区：
文献类型：
--
作者：
NEWSOMDAVIS, J;PINCHING, AJ;WILSON, SG
Plasma exchange was used to investigate the function of anti-acetylcholine receptor (anti-AChR) antibody in 7 patients with acquired myasthenia gravis (MG) who had elevated antibody titers and in 1 patient with congenital MG who had normal titers. There was an inverse association between clinical indices of muscle strength and anti-AChR titers, with a minimum time lag of 2 days for the clinical response. The inverse association of the clinical state with anti-AChR antibody titers was closer than that with total immunoglobulin [Ig] G or other Ig, and is consistent with the view that the anti-AChR antibody is the principal factor interfering with neuromuscular transmission in acquired MG.
