Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala
Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala
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DOI：
10.1016/j.neuroimage.2006.09.046
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发表时间：
2007-02-01
期刊：
影响因子：
5.7
通讯作者：
Barbas, H.
中科院分区：
文献类型：
--
作者：
Ghashghaei, Ht;Hilgetag, C. C.;Barbas, H.
前额叶皮质和杏仁核在调节有目的的行为方面具有协同作用，这种作用是通过双向通路实现的。在这里，我们使用杏仁核内注射的神经示踪剂，研究了恒河猴与杏仁核相连的额叶前部输入-输出区的未知范围和板层关系。前额叶与杏仁核的联系差异很大，后内侧皮质和后内侧皮质的联系最密集，前外侧前额叶区域最稀疏，尤其是第10区。前额叶投射神经元主要投射到杏仁核的第5层，但在后内侧和眶前皮质的第2层和第3层也有大量投射神经元。杏仁核轴突终末在前额叶皮质最常见的分布是浅层和深层的双板带，由横跨整个皮质深度的柱状分布，较少的是以浅层或深层为中心的小斑块。1-2层的大量终末与Calbindin阳性抑制性神经元重叠。对输入和输出投射的关系的比较表明，在连接最紧密的皮质中，扣带回25区和24区向杏仁核发出的投射相对多于它们接收的投射，而尾侧眶前区是接收者多于发送者。此外，从第2-3层的“前馈”皮质投射的比例与支配前额叶皮质浅层的“反馈”终止之间存在显著的关系。这些发现表明，前额叶皮质和杏仁核之间的连接遵循与皮质连接相似的模式，并通过类比提出了情绪信息处理序列背后的路径。(C)2006 Elsevier Inc.保留所有权利。
The prefrontal cortex and the amygdala have synergistic roles in regulating purposive behavior, effected through bidirectional pathways. Here we investigated the largely unknown extent and laminar relationship of prefrontal input-output zones linked with the amygdala using neural tracers injected in the amygdala in rhesus monkeys. Prefrontal areas varied vastly in their connections with the amygdala, with the densest connections found in posterior orbitofrontal and posterior medial cortices, and the sparsest in anterior lateral prefrontal areas, especially area 10. Prefrontal projection neurons directed to the amygdala originated in layer 5, but significant numbers were also found in layers 2 and 3 in posterior medial and orbitofrontal cortices. Amygdalar axonal terminations in prefrontal cortex were most frequently distributed in bilaminar bands in the superficial and deep layers, by columns spanning the entire cortical depth, and less frequently as small patches centered in the superficial or deep layers. Heavy terminations in layers 1-2 overlapped with calbindin-positive inhibitory neurons. A comparison of the relationship of input to output projections revealed that among the most heavily connected cortices, cingulate areas 25 and 24 issued comparatively more projections to the amygdala than they received, whereas caudal orbitofrontal areas were more receivers than senders. Further, there was a significant relationship between the proportion of 'feedforward' cortical projections from layers 2-3 to 'feedback' terminations innervating the superficial layers of prefrontal cortices. These findings indicate that the connections between prefrontal cortices and the amygdala follow similar patterns as corticocortical connections, and by analogy suggest pathways underlying the sequence of information processing for emotions. (c) 2006 Elsevier Inc. All rights reserved.